Preparation of polymyxin B-loaded gellan–polylysine polyion complex fibers with high affinity to endotoxin

Advances in the Development of Biomaterials for Endotoxin Adsorption in Sepsis

“…For instance, PMB was successfully conjugated with a nanofiber sponge made of polyacrylonitrile nanofiber and SiO 2 nanofiber (Huang et al, 2019), in which Q m was calculated as 17,889 EU/g from the Langmuir equation, and the endotoxin removal rate reached 90% in human plasma at a low concentration. Gellanpolylysine complex fiber was also used as the matrix for PMB, which exhibited a Q m of 2,784 EU/g (Peng et al, 2020). Besides, Lambadi et al prepared PMB-capped silver nanoparticles as potential endotoxin adsorbents, which not only removed 97% of endotoxin in aqueous solution remarkably but also enhanced the antimicrobial activity of the silver nanoparticles against multiple drug-resistant clinical strains.…”