Preparation of polyurethane–alginate/chitosan core shell nanoparticles for the purpose of oral insulin delivery

Bhattacharyya, Amitava; Mukherjee, Debarati; Mishra, Roshnara; Kundu, Patit Paban

doi:10.1016/j.eurpolymj.2017.05.015

Cited by 73 publications

(36 citation statements)

References 34 publications

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“…Hydrophilic polyurethane, chitosan, and alginate were used to formulate insulin‐loaded core–shell nano‐particle which protects the protein from enzymatic degradation while passing through stomach. Presence of polyurethane along with alginate improved the nano‐particle characteristics as observed in our previous reports . Incorporation of PU in Chitosan/Alginate core–shell is expected to offer better pharmacological behavior as well as improved insulin bioavailability.…”

Section: Introductionsupporting

confidence: 76%

“…Biodegradable and biocompatible polyurethane was synthesized using depolymerized product of PET. Use of the synthesized polyurethane showed significant improvements in our previously reported formulations and further enhancement in the present research. Chitosan and polyurethane‐chitosan nano‐spheres were formed using the simple coacervation method.…”

Section: Resultsmentioning

confidence: 99%

“…The monomer was separated from the reaction product by filtration process followed by hot water treatment. Removal of catalytic residue from the reaction product was carried out to elude toxic effects as per previously described method . Purified and vacuum dried BHET was used as one of the diols to synthesize polyurethane.…”

Section: Methodsmentioning

confidence: 99%

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Polyurethane‐incorporated chitosan/alginate core–shell nano‐particles for controlled oral insulin delivery

Bhattacharyya

Nasim

Mishra

et al. 2018

J of Applied Polymer Sci

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Chitosan (CS) and polyurethane-chitosan (PU-CS) nano-particles (NPs) were prepared for the core formation by complex coacervation method whereas alginate (ALG) and PU-ALG were crosslinked by ionic gelation method to form the protective shelllayer over the core. Effects of PU incorporation either within the core or shell or both were investigated by different in vitro and in vivo parameters. Fourier transform infrared (FTIR) spectroscopy of different compositions of nano-particles showed distinct characteristic peaks for CS, PU, and ALG, indicating their presence in variable ratios. Significance of polyurethane-incorporated systems towards insulin encapsulation efficiency, swelling parameters, insulin release, and in vivo pharmacological effect were also studied. Particle sizes, zeta potential, morphological analysis, mucoadhesion study, and in vivo acute toxicity studies of these core-shell nanoparticles were also performed. Bioavailability of insulin ranged from 9.04% to 11.6% for polyurethane-incorporated chitosan-alginate core-shell nano-particle formulations which was significantly higher than the insulin bioavailability of basic CS/ALG core-shell nanoparticle system.

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Section: Introductionsupporting

confidence: 76%

Section: Resultsmentioning

confidence: 99%

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Polyurethane‐incorporated chitosan/alginate core–shell nano‐particles for controlled oral insulin delivery

Bhattacharyya

Nasim

Mishra

et al. 2018

J of Applied Polymer Sci

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“…Insulin‐loaded polyurethane‐alginate/chitosan nanoparticles controlled the release of the entrapped hormone and the mucoadhesive nature played an important role in the hypoglycaemic effect noticed on fasted Swiss albino mice. The histopathological studies suggest the safe use of the developed nanoparticles to deliver insulin orally …”

Section: Less Invasive Insulin Deliverymentioning

confidence: 99%

“…The histopathological studies suggest the safe use of the developed nanoparticles to deliver insulin orally. [131] In a recent study, hydrophobic ion pairing technology has been employed to complex insulin with sodium deoxycholate. Insulin-sodium deoxycholate complex improved the liposolubility of insulin and enhanced encapsulation efficiency of insulin complex in poly(lactide-co-glycolide) (PLGA).…”

Section: Formulation Barriermentioning

confidence: 99%

Oral insulin delivery: existing barriers and current counter-strategies

Gedawy

Martinez

Al‐Salami

et al. 2018

Journal of Pharmacy and Pharmacology

134

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Objectives The chronic and progressive nature of diabetes is usually associated with micro-and macrovascular complications where failure of pancreatic b-cell function and a general condition of hyperglycaemia is created. One possible factor is failure of the patient to comply with and adhere to the prescribed insulin due to the inconvenient administration route. This review summarizes the rationale for oral insulin administration, existing barriers and some counter-strategies trialled. Key findings Oral insulin mimics the physiology of endogenous insulin secreted by pancreas. Following the intestinal absorption of oral insulin, it reaches the liver at high concentration via the portal vein. Oral insulin on the other hand has the potential to protect pancreatic b-cells from autoimmune destruction. Structural modification, targeting a particular tissue/receptor, and the use of innovative pharmaceutical formulations such as nanoparticles represent strategies introduced to improve oral insulin bioavailability. They showed promising results in overcoming the hurdles facing oral insulin delivery, although delivery is far from ideal. Summary The use of advanced pharmaceutical technologies and further research in particulate carrier system delivery predominantly nanoparticle utilization would offer useful tools in delivering insulin via the oral route which in turn would potentially improve diabetic patient compliance to insulin and the overall management of diabetes.

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Novel strategies to oral delivery of insulin: Current progress of nanocarriers for diabetes management

Abdel-Moneim

Ramadan

2021

Drug Development Research

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Diabetes mellitus is one of the most serious public health problems in the world. Repeated daily injections of subcutaneous insulin is the standard treatment for patients with type 1 diabetes mellitus; however, subcutaneous insulin injections can potentially cause local discomfort, patient noncompliance, hypoglycemia, failure to regulate glucose homeostasis, infections, and fat deposits at the injection sites. In recent years, numerous attempts have been made to produce safe and efficient nanoparticles for oral insulin delivery. Oral administration is considered the most effective alternative route to insulin injection, but it is accompanied by several challenges related to enzymatic proteolysis, digestive breakdown, and absorption barriers. A number of natural and synthetic polymeric, lipid‐based, and inorganic nanoparticles have been investigated for use. Although improvements have recently been made in potential oral insulin delivery systems, these require further investigation before clinical trials are conducted. In this review, new approaches to oral insulin delivery for diabetes treatment are discussed, including polymeric, lipid‐based, and inorganic nanoparticles, as well as the clinical trials performed for this purpose.

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Preparation of polyurethane–alginate/chitosan core shell nanoparticles for the purpose of oral insulin delivery

Cited by 73 publications

References 34 publications

Polyurethane‐incorporated chitosan/alginate core–shell nano‐particles for controlled oral insulin delivery

Polyurethane‐incorporated chitosan/alginate core–shell nano‐particles for controlled oral insulin delivery

Oral insulin delivery: existing barriers and current counter-strategies

Novel strategies to oral delivery of insulin: Current progress of nanocarriers for diabetes management

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