Preparation of Potassium Glycinatotrihydroxonitrosylruthenate(II)

Abstract

A new mono-glycinato complex of hydroxonitrosylruthenium(II), K[Ru(gly)(OH)3NO] was isolated by use of ion exchange resin from the product formed by the reaction of [RuCl3(H2O)2NO] with glycine. The complex was characterized by means of infrared, visible, and ultraviolet absorption spectra, capillary type isotachophoresis, magnetic moment and molar conductivity.

Ruthenium-Nitrosyl Complexes with Glycine, l-Alanine, l-Valine, l-Proline, d-Proline, l-Serine, l-Threonine, and l-Tyrosine: Synthesis, X-ray Diffraction Structures, Spectroscopic and Electrochemical Properties, and Antiproliferative Activity

“…CD data are given as the differences in molar absorptivities between left and right circularly polarized light, based on the concentration of the ligand (Δε = ΔA/l/c complex ). The concentrations for the UV−vis measurements amounted to 403 (1), 401 (4), 401 (5), 400 (8), 399 (3), 401 (2), 403 (7), and 401 (6) μM.…”

“… 4 Given the importance of NO as a noninnocent ligand in coordination chemistry, 5 the occurrence of structural trans effects (STEs), the role of the metal-nitrosyl unit as a reaction mediator or regulator of geometry around the metal ion, 6 as well as linkage isomerization of the N- and O-bound nitrosyl ligand, 7 surprisingly little is known about the reactivity of ruthenium(II)- and osmium(II)-nitrosyl compounds with respect to amino acids. Although a few ruthenium-nitrosyl complexes with amino acids and related ligands have been reported in the literature, for example, K[Ru(Gly)(OH) 3 NO], 8 K[Ru( l -Ala)(OH) 3 NO], 9 [RuCl 2 ( l -His)(NO)], 10 [RuCl 2 ( l -Met)(NO)], 11 and (C 2 H 5 ) 4 N[RuCl 3 (pyca)(NO)], 12 where pycaH = 2-pyridinecarboxylic acid, their antiproliferative activity remains unknown. All this prompted us to continue our recently initiated study 13 on the interaction of [MCl 5 (NO)] 2– with different amino acids as a benchmark for further investigation of the reactivity of ruthenium and osmium nitrosyl complexes with azole heterocycles toward amino acids (AA).…”

Crystal structure of the ruthenium(II) nitrosotrichloro complex Na[RuNOCl3(H2O)OH]·2H2O

“…At most, potassium or ammonium salts of the nitrosopentachlororuthenate anion are used in the syntheses [1][2][3][4][5], these salts being readily available with good yields from ruthenium thrichloride [6]. However, these salts are insoluble in organic solvents and when reactions are carried out in non-aqueous media, the starting ruthenium compound is the nitrosotrichloro complex RuNOCl 3 nH 2 O [7][8][9][10][11][12]. The ability of the ethanolic solution of this compound to readily react with many organic ligands affording stable uncharged [RuNOL 2 Cl 3 ] complexes was noted as early as in 1966 by Fairy and Irving [13].…”