Preparation of potential 3-deazauridine and 6-azauridine prodrugs through an enzymatic alcoholysis

Preparation of Polyglycidylmethacrylate Macropore Beads and Application in Candidaspecies 99–125 Lipase Immobilization

“…Specifically, lipases as a very important branch of enzymes could be employed to catalyze hydrolysis, alcoholysis, esterification and transesterification of carboxylic esters [1][2][3]. Using these reactions, synthetic processes could be designed to obtain a wide range of products under mild and environmentally friendly conditions.…”

Recognition of acyl donors by lipase CAL‐B in the acylation of 6‐azauridine

“…To our knowledge, there has been no report on the enzymatic acylation of AzUrd. The only attempt to prepare the acylated derivatives was made by Zinni et al, who synthesized 2′,3′‐di‐ O ‐acylated derivatives of AzUrd with good yields (80.0–99.0%) through regioselective deacylation of the peracylated derivatives 20…”

An improved regioselective preparation of methyl 2,3-di-O-acetyl-α,β-d-xylofuranoside

“…Previous studies by us showed that the alcohol/substrate (A/S) ratio affects the regioselectivity of CAL-B catalysed alcoholysis, a better regioselectivity have been reached at very high A/S ratios (A/S Ͼ 100) in the deacetylation of furanoses (I ñ igo et al 2005;Gudi ñ o et al 2009;Gudi ñ o et al 2010) and nucleosides (Zinni et al 2007;Sabaini et al 2010;Ferrero & Gotor 2000a, 2000b, Li et al 2010. Thus, we tested CAL-B catalysed alcoholysis of 1 at A/S ϭ 1200, 660 and 120; the former ratio gave a poor conversion of the substrate, while the latter two did not provide regioselective reactions.…”