Preparation of Redox-Sensitive Shell Cross-Linked Nanoparticles for Controlled Release of Bioactive Agents

Abstract

Redox-sensitive shell cross-linked (SCL) poly­(2-(dimethylamino)­ethyl methacrylate)-block-polystyrene (PDMAEMA-b-PS) nanoparticles have been facilely fabricated by surfactant-free emulsion reversible addition–fragmentation chain transfer polymerization (SFE-RAFT), in which amphiphilic C12H25–PDMAEMA copolymers acted as stabilizers. 1H NMR, dynamic light scattering (DLS), and transmission electron microscopy (TEM) were applied to investigate the compositions and the morphologies of the resultant nanoparticles. Then, the as-prepared nanoparticles were used as a carrier to encapsulate of hydrophobic drugs, and the release could be triggered by a redox reagent, dithiothreitol (DTT). The SCL nanoparticles had a good biocompatibility. These properties indicated that these nanoparticles would be used as promising drug delivery vehicles.

Photo-induced synthesis glucose-responsive carriers for controlled release of insulin in vitro

“…The average diameter determined by DLS is larger than that determined by TEM. This discrepancy is widely considered to be induced by the process of sample preparation and the difference of investigation method between DLS and TEM [22][23][24][25].…”

Porous Carbons – Hyperbranched Polymers – Polymer Solvation

“…For instance, glutathione allowed the release of disulfide shell-crosslinked micelles [287]. Similar principles hold true for core-crosslinked micelles/nanoparticles/stars [288,289]. But, as already mentioned, this chemistry is seldom applicable for electrochemical switching.…”

“…Suda et al [288] reported the synthesis and characterization of a series of sulfonated star-hb polyimides (S-hb-PIs) without any crosslinking for use as proton exchange membranes. Sulfonated anhydride-terminated polyimides with different molecular weights (M w ¼ 59,000, 200,000 and 300,000 Da) based on monomer combination 1,4,5,8-naphthalene tetracarboxylic dianhydride/4,4 0 -diaminobiphenyl 2,2 0disulfonic acid (NTDA/BDSA) were synthesized using different molar ratios of BDSA:NTDA.…”

Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs

“…Commonly used core-forming hydrophobic polymers for drug delivery can be classified into the following groups: poly(propylene oxide) (PPO) as in Pluronics ®17 ; poly(esters) such as poly(lactic acid) (PLA) 18 and poly(ε-caprolactone) (PCL) 19, 20 ; poly(L-amino acids) such as poly(L-lysine) 21 ; and phospholipids and lipid-derivatives such as phosphatidyl ethanoloamine 22 . In addition, core-forming polymers such as polystyrene have been used in both in drug delivery systems 23 as well as fundamental research regarding polymer micelles 24 . These core-forming constituents cover a wide range of structural diversity and polarity for solubilizing a wide range of poorly water-soluble drugs.…”