Preparation of samarium-153-EDTMP and determination of its radiochemical purity using paper chromatography

Gasiglia, H.T.; Okada, Helena

doi:10.1007/bf02162455

Cited by 13 publications

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“…Preparation of Na 5 [Sm-EDTMP] was accomplished following previously published methods . Briefly, the pH of an aqueous solution containing 0.004 mol (1.74 g) of H 8 EDTMP was raised to pH 12 by the addition of aqueous NaOH (0.032 mol, 1.28 g) producing the EDTMP 8– ligand, followed by the addition of 0.004 mol of SmCl 3 ·6H 2 O (1.46 g); the light yellow reaction mixture was heated at 60 °C for 1 h (pH 7, using pH paper), as depicted in Scheme .…”

Section: Methodsmentioning

confidence: 99%

“…Preparation of Na 5 [Sm-EDTMP] was accomplished following previously published methods. 11 Briefly, the pH of an aqueous solution containing 0.004 mol (1.74 g) of H 8 EDTMP was raised to pH 12 by the addition of aqueous NaOH (0.032 mol, 1.28 g) producing the EDTMP 8− ligand, followed by the addition of 0.004 mol of SmCl 3 •6H 2 O (1.46 g); the light yellow reaction mixture was heated at 60 °C for 1 h (pH 7, using pH paper), as depicted in Scheme 1. The resulting white solid product was precipitated by dropwise addition of methanol, then filtered, and washed with additional methanol.…”

Section: ■ Introductionmentioning

confidence: 99%

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Structural Characterization of Sm^III(EDTMP)

et al. 2015

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Samarium-153 ethylenediamine-N,N,N',N'-tetrakis(methylenephosphonic acid) ((153)Sm-EDTMP, or samarium lexidronam), also known by its registered trademark name Quadramet, is an approved therapeutic radiopharmaceutical used in the palliative treatment of painful bone metastases. Typically, patients with prostate, breast, or lung cancer are most likely to go on to require bone pain palliation treatment due to bone metastases. Sm(EDTMP) is a bone-seeking drug which accumulates on rapidly growing bone, thereby delivering a highly region-specific dose of radiation, chiefly through β particle emission. Even with its widespread clinical use, the structure of Sm(EDTMP) has not yet been characterized at atomic resolution, despite attempts to crystallize the complex. Herein, we prepared a 1:1 complex of the cold (stable isotope) of Sm(EDTMP) under alkaline conditions and then isolated and characterized the complex using conventional spectroscopic techniques, as well as with extended X-ray absorption fine structure (EXAFS) spectroscopy and density functional structure calculations, using natural abundance Sm. We present the atomic resolution structure of [Sm(III)(EDTMP)-8H](5-) for the first time, supported by the EXAFS data and complementary spectroscopic techniques, which demonstrate that the samarium coordination environment in solution is in agreement with the structure that has long been conjectured.

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Section: Methodsmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Structural Characterization of Sm^III(EDTMP)

et al. 2015

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“…In vivo behavior of 153Sm-EDTMP is independent of the amount of EDTMP at 1 hour post injection but at 24 hour post injection the liver uptake of this complex significantly decreases whereas bone uptake decreases lightly with increasing amount of injected EDTMP. [51][52][53][54][55] It has been observed that 153Sm particulate hydroxyapatite (153Sm-HYP) has two major advantages, namely, the particle size can be controlled prior the radiolabeling procedure and particulate hydroxyapatite is a natural constituent of bone. 56 The clinical outcome and tolerability of 153Sm-HYP was evaluated in patients with persistent rheumatoid knee synovitis.…”

Section: Therapeutic Applicationsmentioning

confidence: 99%

Application of radioisotopes in the field of nuclear medicine

Nayak

Lahiri

1999

J Radioanal Nucl Chem

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A comprehensive review has been made to discuss the role of various radionuclides of lanthanide series elements in the field of nuclear medicine. The role of several pharmaceuticals labeled with radiolanthanides and used for investigative purposes like measurement of cerebral blood flow, bone density measurement, bone marrow imaging, etc., have been described. The role of lanthanide radionuclides in radiation synovectomy, radioimmunotherapy, etc., have also been discussed. Methods of preparation of some representative radiopharmaceuticals like lS3Sm-EDTMP, 153Sm-HYP, have been presented. An outline on the production of carrier free radioisotopes oflanthanide series elements has been given.

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“…Various phosphonates, in turn, have been widely applied, e.g. in medical diagnostics (Winter et al, 1998), therapy (Gasiglia & Okada, 1995;Finlay et al, 2005;Schwartz, 2006) and agriculture. The importance of these compounds has prompted extensive experimental and theoretical investigations.…”

Section: Introductionmentioning

confidence: 99%

Charge density distribution in aminomethylphosphonic acid

Janicki

Starynowicz

2010

Acta Crystallogr Sect B

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The experimental charge density distribution in aminomethylphosphonic acid has been determined from X-ray diffraction and its topological features have been analyzed. The results have shown that the P-O bonds are highly polarized, moreover the P-OH bond is weaker than the bonds to unprotonated O atoms. These facts have been confirmed by theoretical density functional theory (DFT) calculations, which have shown that the single, strongly polarized bonds within the phosphonate group are modified by hyperconjugation effects.

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Preparation of samarium-153-EDTMP and determination of its radiochemical purity using paper chromatography

Cited by 13 publications

References 2 publications

Structural Characterization of Sm^III(EDTMP)

Structural Characterization of Sm^III(EDTMP)

Application of radioisotopes in the field of nuclear medicine

Charge density distribution in aminomethylphosphonic acid

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Preparation of samarium-153-EDTMP and determination of its radiochemical purity using paper chromatography

Cited by 13 publications

References 2 publications

Structural Characterization of SmIII(EDTMP)

Structural Characterization of SmIII(EDTMP)

Application of radioisotopes in the field of nuclear medicine

Charge density distribution in aminomethylphosphonic acid

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Product

Resources

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Structural Characterization of Sm^III(EDTMP)

Structural Characterization of Sm^III(EDTMP)