Preparation of Shell Cross‐Linked Micelles by Polyelectrolyte Complexation

One‐Pot Synthesis of Micelles with a Cross‐Linked Poly(acrylic acid) Core

“…During the past two decades, extensive investigations have been made in order to stabilize the micelles by crosslinking their core or shell. [24][25][26][27][28][29] In spite of the great efforts made in this area, the cross-linking reactions have been carried out at only a relatively low concentration and for long time, for example, in 0.2 g Á mL À1 for 5 d, [30] or in 10% w/v for at least 72 h. [31] If the block copolymerization of monovinyl and divinyl monomers with a macroinitiator is carried out in a selective solvent, the microphase separation of the block copolymers formed in situ might form micelles, and continued polymerization may occur in the micelles to form core cross-linked micelles (Scheme 2). Thus, the controlled block copolymerization and selfassembly of block copolymers as well as the core crosslinking reaction can occur in one pot.…”

Polyester Dendrimers: Smart Carriers for Drug Delivery

“…For example, the complexation of opposite charged PEG block copolymers with cationic amino methacrylates or anionic styrene sulfonates has been explored [109]. Polymer-drug partners with specific acid-base interactions between hydrophobic drug molecules (R 1 -COOH) and polymer segments (NH 2 -R 2 ) improved the drug loading capacity [110].…”

Tertiary Amine Methacrylate‐Based ABC Triblock Copolymers: Synthesis, Characterization, and Self‐Assembly in both Aqueous and Nonaqueous Media

“…[13] During the last decade, it has been shown that ABC triblock copolymers offer significant advantages over AB diblock copolymers for the preparation of SCL micelles. [14][15][16][17][18] Many strategies have been developed so far for the shell cross-linking of micelles and these include carbodiimide coupling, [19] 1,2-bis(2-iodoethoxy)ethane (BIEE), [14,15,18,20] divinyl sulfone (DVS), [21] glutaraldehyde, [22] polyelectrolyte complexation, [23,24] activated esters, [25] click chemistry, [26] metal-catalyzed cross-linking [27] and UV irradiation. [28,29] Possessing the properties of micelles, microgels, nanoparticles, and dendrimers, SCL micelles with stimuliresponsive coronas are preferred in practical applications, such as targeted drug delivery, tunable release, recyclable catalysts, emulsification, sequestration of metabolites and entrapment of environmental pollutants.…”