Preparation of silica/polymer nanocomposites with aggregation-induced emission properties as fluorescent responsive coatings

Li, Weili; Qiu, Zhenyu; Tebyetekerwa, Mike; Zhang, Jin; Wang, Yong; Gao, Tian; Wang, Jun; Ding, Yexing; Xie, Yixiao

doi:10.1016/j.porgcoat.2018.11.001

Cited by 18 publications

(7 citation statements)

References 25 publications

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“…Functional coatings are particularly useful in the medical field for the prevention of microbial colonization on implants [8] and medical devices [9][10][11][12][13], to ensure drug delivery and sustained release of bioactive agents [14][15][16][17][18] as well as to minimize protein adsorption on medical devices [19]. Polymeric coatings containing fluorescent dyes are interesting for many applications including optical sensors [20][21][22][23], stimuli responsive smart materials [24][25][26], and, ultimately, in medical imaging and fluorescence-guided surgery [27][28][29][30]. Currently, the medical field is mainly dominated by other imaging modalities, such as X-ray radiography, computed tomography (CT), magnetic resonance imaging (MRI), ultra-sonography, positron emission tomography (PET), etc., but they have several limitations [31].…”

Section: Introductionmentioning

confidence: 99%

Near-infrared fluorescent coatings of medical devices for image-guided surgery

et al. 2020

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Rapidly expanding field of image-guided surgery needs new materials for near-infrared imaging with deep tissue penetration. Here, we introduce near-infrared coating of equipment (NICE) for image-guided surgery based on a series of lipophilic cyanine-7.5 dyes with bulky hydrophobic counterions and a biocompatible polymer, poly(methyl methacrylate). The NICE material exhibits superior brightness (15-20-fold higher) and photostability compared to fluorescent coatings based on commonly used indocyanine green (ICG). It can be deposited on different surfaces and devices, such as steel and gold fiducials, silicone and PVC catheters, polymeric surgical sutures and gauzes. Such coated medical devices show excellent stability in air and buffer for 150 days. Accelerated ageing revealed their shelf-life of 3 years. They are also stable in serum-containing media, whereas ICG-based coating shows rapid dye leakage. NICE is compatible with standard sterilization protocols based on ethylene oxide and vapor. Moreover, our coating material is biocompatible, where cultured cells spread effectively without signs of cytotoxicity. Ex vivo studies suggest that NICE on fiducials can be visualized as deep as 0.5 cm, and NICE on catheters enables their visualization inside ureters and esophagus. Finally, NICE on different medical devices has been validated for image-guided surgery in porcine and human cadaver models. Thus, the developed NIR coating material emerges as a powerful tool for a variety of medical applications.

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Section: Introductionmentioning

confidence: 99%

Near-infrared fluorescent coatings of medical devices for image-guided surgery

et al. 2020

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“…Polysiloxane has also been used to functionalize cotton fabrics, however classical polysiloxanes without reactive functional groups have poor adhesion to cotton fibers and poor durability of bonding with cellulose surface. 25 Fortunately, polysiloxanes can be easily functionalized 26 by introducing functional groups to their structures. Therefore, their deficiency could be modified by other resins.…”

Section: Introductionmentioning

confidence: 99%

Fabricating self‐stratifying coating for superhydrophobic cotton textile

et al. 2021

J of Applied Polymer Sci

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In this paper, a type of superhydrophobic cotton textile was designed and prepared. Particularly, it was obtained by coating a type of acrylic-silicone hybrid resin onto the cotton fabric. With self-stratifying character, the cured coating can be formed into two layers, in which the acrylic component in the bottom layer enables polar bond or hydrogen bond linkage with cellulose molecules on the fiber surface, while the amino silicone oil resin on the surface layer acts as a functional part and adds new surface features to the cotton fabric. As a result, the coated cotton fabric displayed superhydrophobicity, with a water contact angle above 150 and a rolling angle less than 8 . The experimental findings indicated that the fabricated textile had adequate mechanical strength to withstand sandpaper abrasion for 20-cycles abrasion by pressing a constant load of 500 g. Additionally, the modified textiles exhibited stable oil-water separation abilities, therefore showing multifunctional properties that have potential applications in many cotton textile surface treatments.

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“…Amphiphilic block copolymers, a research focus of nanomaterials, can self-assemble into nanoaggregates in selective solvents, which is commonly used to load hydrophobic drugs, genes, and proteins and for biological imaging. [1][2][3] When used as drug carriers, drug-loaded micelles self-assembled can increase the solubility of hydrophobic drugs such as ibuprofen, paclitaxel, and doxorubicin, [4][5][6][7][8] reduce side effects and prolong drug half-life. Zhao's group rst prepared photosensitive micelles, and polyethylene glycol-b-poly(o-nitrobenzyl methacrylate) block copolymer was synthesized by atom transfer radical polymerization (ATRP), which self-assembled into micelles in aqueous solution.…”

Section: Introductionmentioning

confidence: 99%