Preparation of Simvastatin Loaded TiO2 nanotube arrays and its release behavior

Abstract

Abstract. TiO 2 nanotube array fabricated by anodization has large specific surface area and good biocompatibility. The simvastatin (SIM), which can promote bone formation, were filled into the TiO 2 nanotube by using step concentration soaking method(SCS).The morphology of TiO 2 nanotube arrays were observed by scanning electronic microscope, and the drug release in phosphate buffer solution (PBS) were determined by visible ultraviolet spectrophotometer. The results show that the simvatatin has been loaded into the TiO 2 nanotube arrays, and could sustain release 15 days.