Preparation of size-controlled (30–100 nm) magnetite nanoparticles for biomedical applications

Development of novel magnetic nano-carriers for high-performance affinity purification

“…Magnetite particles were synthesized by oxidizing ferrous hydroxide by sodium nitrate in aqueous NaOH as described previously [19]. NaNO 3 (0.75 g, 8.80 mmol) was added into a 21 mM aqueous NaOH solution (475 ml, pH 12-13), which was deaerated by N 2 gas.…”

Novel Applications of Affinity Beads

“…These MNPs are suitable as a magnetic core for subsequent coating with functional molecules to accomplish quick and effective response in magnets [6]. …”

“…Our initial effort was focused on preparing uniformly sized magnetite particles (MP 1 ) greater than 10 nm in size, because larger MP 1 have potentially higher magnetization and respond more rapidly to a permanent magnet then do the magnetite nanoparticles commonly used. We prepared size-controlled MPs of several dozen nanometers using a wet process according to our previous study [6]. MPs were separated from solution with a magnet and washed several times with pure water.…”

Synthesis and Characterization of Magnetic Methyl Methacrylate Microspheres Loaded with Indomethacin by Emulsion Solvent Evaporation Technique.

“…1-2 mm) would be more advantageous than nanospheres in terms of better targeting and easier capture [20][21][22][23][24] . To do this, one of the main challenges has been the fabrication of magnetic spheres with high magnetizations, good drug encapsulation efficiency and high drug payload [25][26] . This generally requires that the magnetic carriers are biodegradable, smaller than red blood cells (i.e.…”