Preparation of size-controlled polymer particles by polymerization of O/W emulsion monomer droplets obtained through phase inversion temperature emulsification using amphiphilic comb-like block polymers

Sasaki, Yusuke; Konishi, Naho; Kasuya, Masakatsu; Kohri, Michinari; Taniguchi, Tadatsugu; Kishikawa, Keiki

doi:10.1016/j.colsurfa.2015.04.019

Cited by 22 publications

(5 citation statements)

References 78 publications

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“…In the case of amphiphilic species obtained via RAFT polymerization, it is possible to correlate the NP Dn with the monomer units of the lipophilic part ( p in this work) according to eq : where MW HEMA–CL q is the molecular weight of the lipophilic monomer, ρ b_lipo the density of the lipophilic part of the block copolymer, N avo the Avogadro number, and A Cov the surface area that the hydrophilic part of the block copolymer can cover. This equation has been derived from the hypothesis that the NP size depends on the number of the amphiphiles and on the volume that their lipophilic portion is able to occupy, a behavior well-documented in the literature , (we leave the detailed demonstration and explanation of eq to ref ). As visible in Figure a, Dn is a linear function of p for the poly(CB) and poly(MPC)-based block copolymers synthesized with q = 5.3, as predicted from eq .…”

Section: Resultsmentioning

confidence: 99%

Zwitterionic Polyester-Based Nanoparticles with Tunable Size, Polymer Molecular Weight, and Degradation Time

et al. 2018

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Biodegradable polymer nanoparticles are an important class of materials used in several applications for their unique characteristics. In particular, the ones stabilized by zwitterionic materials are gaining increased interest in medicine as alternative to the more common ones based on poly(ethylene glycol) thanks to their superior stability and ability to avoid both the accelerated blood clearance and allergic reactions. In this work, a novel class of zwitterionic based NPs has been produced, and a method to independently control the nanoparticle size, degradation time, and polymer molecular weight has been developed and demonstrated. This has been possible by the synthesis and the fine-tuning of zwitterionic amphiphilic block copolymers obtained via the combination of ring-opening polymerization and reversible addition-fragmentation chain transfer polymerization. The final results showed that when two block copolymers contain the same number of caprolactone units, the one with longer oligoester lateral chains degrades faster. This phenomenon is in sharp contrast with the one seen so far for the common linear polyester systems where longer chains result in longer degradation times, and it can be used to better tailor the degradation behavior of the nanoparticles.

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Section: Resultsmentioning

confidence: 99%

Zwitterionic Polyester-Based Nanoparticles with Tunable Size, Polymer Molecular Weight, and Degradation Time

et al. 2018

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“…For example, below their CPTs, PNIPAm copolymers with 2–5 kDa terminal PS blocks have been reported to exhibit CMCs in the range of ~1–30 µg mL −1 , depending on the molecular weights of both PNIPAm and PS blocks [ 45 , 46 , 47 ]. It was further shown, that thermoresponsive poly[(methoxy diethylene glycol) methacrylate] and POEGMA both equipped with terminal PS blocks of ~1–1.5 kDa exhibit CMCs in water at ~430 and ~50–200 µg mL −1 , respectively [ 48 , 49 , 50 ]. Ge et al investigated the aggregation behavior of PNIPAm (~25–35 kDa) equipped with terminal dendritic G 2 (0.7 kDa) and G 3 (1.6 kDa) poly(benzyl ether) (PBE) blocks [ 51 ], which are similar to the herein reported EBP-based anchor blocks in both chemistry and molecular weight ( Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

Thermoresponsive Poly(glycidyl ether) Brush Coatings on Various Tissue Culture Substrates—How Block Copolymer Design and Substrate Material Govern Self-Assembly and Phase Transition

Stöbener

Weinhart

2020

Polymers

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Thermoresponsive poly(glycidyl ether) brushes can be grafted to applied tissue culture substrates and used for the fabrication of primary human cell sheets. The self-assembly of such brushes is achieved via the directed physical adsorption and subsequent UV immobilization of block copolymers equipped with a short, photo-reactive benzophenone-based anchor block. Depending on the chemistry and hydrophobicity of the benzophenone anchor, we demonstrate that such block copolymers exhibit distinct thermoresponsive properties and aggregation behaviors in water. Independent on the block copolymer composition, we developed a versatile grafting-to process which allows the fabrication of poly(glycidyl ether) brushes on various tissue culture substrates from dilute aqueous-ethanolic solution. The viability of this process crucially depends on the chemistry and hydrophobicity of, both, benzophenone-based anchor block and substrate material. Utilizing these insights, we were able to manufacture thermoresponsive poly(glycidyl ether) brushes on moderately hydrophobic polystyrene and polycarbonate as well as on rather hydrophilic polyethylene terephthalate and tissue culture-treated polystyrene substrates. We further show that the temperature-dependent switchability of the brush coatings is not only dependent on the cloud point temperature of the block copolymers, but also markedly governed by the hydrophobicity of the surface-bound benzophenone anchor and the subjacent substrate material. Our findings demonstrate that the design of amphiphilic thermoresponsive block copolymers is crucial for their phase transition characteristics in solution and on surfaces.

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“…Emulsion polymerization has been widely applied to fabricate gel-type particles with nanoscale diameters and large surface areas. 19,20 However, such a small particle size (from 50 to 500 nm) results in hard isolation of the PPMs from the dispersion medium, which limits their applications. Compared with these aforementioned strategies, suspension polymerization is a more facile technique used in the synthesis of PPMs, due to its high efficiency and low cost and the simple isolation of PPMs from the medium.…”

Section: Introductionmentioning

confidence: 99%

High porosity microspheres with functional groups synthesized by thiol–yne click suspension polymerization

et al. 2016

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Preparation of size-controlled polymer particles by polymerization of O/W emulsion monomer droplets obtained through phase inversion temperature emulsification using amphiphilic comb-like block polymers

Cited by 22 publications

References 78 publications

Zwitterionic Polyester-Based Nanoparticles with Tunable Size, Polymer Molecular Weight, and Degradation Time

Zwitterionic Polyester-Based Nanoparticles with Tunable Size, Polymer Molecular Weight, and Degradation Time

Thermoresponsive Poly(glycidyl ether) Brush Coatings on Various Tissue Culture Substrates—How Block Copolymer Design and Substrate Material Govern Self-Assembly and Phase Transition

High porosity microspheres with functional groups synthesized by thiol–yne click suspension polymerization

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