Preparation of soluble p-aminobenzoyl chitosan ester by Schiff's base and antibacterial activity of the derivatives

Wang, Jiangtao; Wang, Hedong

doi:10.1016/j.ijbiomac.2011.01.016

Cited by 65 publications

(25 citation statements)

References 12 publications

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“…International Journal of Polymer Science bacterium which could cause wound infection. A representative microbe colony was picked off with an inoculating needle, placed in 25 mL sterile nutrient broth, and then incubated in a shaker at a speed of 100 rpm at 37°C for 24 h. The bacterial suspension was then diluted with sterile physiological saline to 10 3 -10 4 CFU/mL and used for the antibacterial test [21,22]. The inhibition rates of CS and ACHA against E. coli, S. aureus, and P. aeruginosa were determined through the use of agar plates [1].…”

Section: Antimicrobialmentioning

confidence: 99%

Synthesis and Characterization of O-Acetyl-chitosan Acetic Ester

Cheng

Wang

Xia

2018

International Journal of Polymer Science

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A novel amphipathic chitosan derivative, O-acetyl-chitosan acetic ester (ACHA), was synthesized by the reaction of chitosan with acetic acid in the presence of thionyl chloride. The physicochemical properties of ACHA were characterized by FTIR, 1 H NMR, TGA, and XRD. The yield (Y) of ACHA was 79.4%, and the degree of acetylation (DA) of ACHA was 1.04. Compared to CS, ACHA could be dissolved in many organic solvents, deionized water, and aqueous solution. Our results showed that ACHA exhibited a superior antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. These findings indicated that ACHA was preferable for use as antimicrobial agents in wound healing, food preservative, and tissue engineering.

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Section: Antimicrobialmentioning

confidence: 99%

Synthesis and Characterization of O-Acetyl-chitosan Acetic Ester

Cheng

Wang

Xia

2018

International Journal of Polymer Science

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“…Chitosan (CS) is a N-deacetylated derivative of chitin that can be effectively degraded into non-toxic, absorbable monosaccharides that are not teratogenic (Bonferoni et al, 2009;Elsabee et al, 2009). It is the second-most naturally abundant biodegradable polymer material and is used in the biomedicine industry due to its antibacterial, antiinflammatory, anti-thrombotic, hemostatic, wound healing, and immunomodulating effects (Wang and Wang, 2011;Lewandowska, 2015). In recent years, chitosan-grafted polymers have been used in cell stents and wound healing polymer dressings in the biomedicine field (Nettles and Elder, 2002;Berger et al, 2004;Kalambettu and Rajangam, 2012).…”

Section: Introductionmentioning

confidence: 99%

Enhanced Healing and Antimicrobial Efficacy of Chitosan-g-Polyacrylamide in a Rat Model of Gingival Ulcers

Zheng

Yin

et al. 2020

Front. Chem.

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Patients in dental hospitals often experience oral ulcerative lesions, which lead to pain and affect the patient's quality of life. At present, the goal of treating oral ulcerative lesions with drugs is to reduce inflammation and promote ulcer healing. However, very few antibacterial and hemostatic drugs are designed to be suitable for the microenvironment of gingival ulcers. Based on this, we have designed a natural therapeutic agent for oral ulcerative lesions that meets the various requirements of oral ulcerative lesion medication. The chitosan-g-polyacrylamide (CP) copolymer is composed of chitosan as the main chain and polyacrylamide polymers as the side chains. Antibacterial experiments show that this polymer can effectively inhibit the proliferation of Gram-negative (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus). In vitro cell experiments also show that the CP copolymer is non-toxic, which is conducive to ulcer wound healing. Coagulation experiments prove that the CP copolymer can accelerate blood coagulation to stop bleeding. In experiments using a Wistar rat gingival ulcer model, the CP copolymer significantly promoted ulcer healing and shortened the healing time. These results indicate that the CP copolymer may serve as a potential therapeutic agent for oral ulcerative lesions.

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“…The pKa value of the primary amino groups in chitosan is determined to be around 6.5 (Strand et al, 2001). Even though chitosan and its derivatives are soluble at pH values of lower than 6 (Wang and Wang, 2011), many of its applications in the neutral or basic media, including those of physiological behaviors, may not be recognized. Therefore, they will trigger an immediate precipitation for the pH under such condition.…”

Section: Introductionmentioning

confidence: 99%

Chemical Modification of Chitosan in order to Inverse Swelling Behavior: Comparison between Crosslinking, Michael Addition and Graft Copolymerization Reactions

et al. 2015

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In the present work, three methods were used to inverse chitosan swelling behavior including, conjugation of p-amino benzoic acid (PABA) on cross-linked chitosan in different condition, Michael addition reaction of acrylic acid (AA) on chitosan and finally graft copolymerization of methacrylic acid (MMA) on chitosan. We couldn't inverse chitosan swelling behavior by the Michael addition reaction of acrylic acid, but conjugation of PABA on cross-linked chitosan inversed the chitosan swelling behavior. In addition, the graft copolymerization of MMA on chitosan was also successful. In general, the third method, among the above-mentioned modifications provided the best results.

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Preparation of soluble p-aminobenzoyl chitosan ester by Schiff's base and antibacterial activity of the derivatives

Cited by 65 publications

References 12 publications

Synthesis and Characterization of O-Acetyl-chitosan Acetic Ester

Synthesis and Characterization of O-Acetyl-chitosan Acetic Ester

Enhanced Healing and Antimicrobial Efficacy of Chitosan-g-Polyacrylamide in a Rat Model of Gingival Ulcers

Chemical Modification of Chitosan in order to Inverse Swelling Behavior: Comparison between Crosslinking, Michael Addition and Graft Copolymerization Reactions

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