Preparation of Starch/Gelatin Blend Microparticles by a Water-in-Oil Emulsion Method for Controlled Release Drug Delivery

Abstract

Information on the preparation and properties of starch/gelatin blend microparticles with and without crosslinking for drug delivery is presented. The blend microparticles were prepared by the water-in-oil emulsion solvent diffusion method. Glutaraldehyde and methylene blue were used as the crosslinker and the water-soluble drug model, respectively. The blend microparticles were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and UV-Vis spectroscopy. The functional groups of the starch and gelatin blend matrices were determined from the FTIR spectra. Blend microparticles with a nearly spherical shape and internal porous structure were observed from SEM images. The average particle size of the gelatin microparticles depended on the crosslinker ratio but not on the starch/gelatin blend ratio. The in vitro drug release content significantly decreased as the crosslinker ratio increased and the starch blend ratio decreased. The results demonstrated that the starch/gelatin blend microparticles should be a useful controlled release delivery carrier for water-soluble drugs.

Study of Molecular Inclusion Complex Formation of Amylose With Indomethacin

“…The reported percentage of the released drug refers to the ratio of the quantified drug mass to the theoretical mass of the drug in the systems. [27][28][29][30] a Samples prepared by the alkaline method are coded with the letter K, whereas those prepared by the sonication method are coded with the letter S. The letter W refer to samples that were washed with water and ethanol/water mixture (50/50), while the code NW refers to samples, that were not washed with water and with ethanol/ water mixture (50/50) before drying. The letters P and A refer to pea starch and amylose, respectively.…”

“…The reported percentage of the released drug refers to the ratio of the quantified drug mass to the theoretical mass of the drug in the systems. [27][28][29][30]…”

A review on introduction and applications of starch and its biodegradable polymers

“…So there is no need for surgical removal of the devices after their drug depletion. Starch/gelatin blend microparticles are proposed to use in controlled release delivery carrier for water soluble drugs (Phromsopha et al, 2014). Starch based polymers are biodegradable and have three major applications in agriculture (Dilara et al, 2000) such as the covering of green house, mulch films and fertilizers.…”

Development and characterization of cross-linked gellan gum and retrograded starch blend hydrogels for drug delivery applications

“…However, natural polysaccharides can present some disadvantages related to their viscosity, swelling, solubility, and stability. Through the blending of polymers or their modification by cross-linking reactions, new materials can be developed with modulated physicochemical properties tailored to the specific requirements of a given application (Bajpai et al, 2008;Carbinatto et al, 2012;Carbinatto et al, 2014;Cury et al, 2009aCury et al, , 2009bMeneguin et al, 2014;Oliveira et al, 2010;Peppas et al, 2000;Prezotti et al, 2014Prezotti et al, , 2012Soares et al, 2013).…”