Preparation of Superparamagnetic Gold Nanocomposites with Different Diameters and Their Imaging and Therapy Applications

Zhai, Yuling; Zhai, Yun; Di, Wen; Wu, Dong; Gao, Yong Ping; Gao, Yongping; Niu, Dechao; Niu, De Chao; Chen, Jian Zhuang; Chen, Jianzhuang; Gu, Jian; Jin-Lou, Gu; Li, Yong Sheng; Li, Yongsheng; Shi, Jianlin; Shi, Jian Lin

doi:10.15541/jim20150077

Cited by 7 publications

(1 citation statement)

References 11 publications

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“…(3)Confirm the best ratio of active Al 2 O 3 and nanometer TiO 2 [9]. (4)Measure the pavement friction coefficient, and take measures to enhance the skid resistance.…”

Section: Experiments Experimental Considerationsmentioning

confidence: 99%

Safe and Eco-Friendly Haze-Eliminating Pavement Coating

Zhang

Wang

et al. 2014

AMR

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The main purpose of the pavement coating is to reduce the haze by absorbing and degrading pm2.5 from automobile exhaust. Based on the investigation and analysis of the source and main composition of haze and pm2.5 and the physical and chemical properties of haze, the paper proposes the method of combining the absorption and catalytic degradation of active Al2O3 and nanometer TiO2 together. Through the experiments, the pavement coating which has the different ratio of active Al2O3 and nanometer TiO2 behaves differently on the effect of absorption and degradation of pm2.5, and the optimum dosage and ratio of active Al2O3 and nanometer TiO2 was found finally. The pavement coating which use the optimum dosage has the more obvious effect under the ultraviolet. And the water resistance and skid resistance performance can also meet the requirements.

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“…(3)Confirm the best ratio of active Al 2 O 3 and nanometer TiO 2 [9]. (4)Measure the pavement friction coefficient, and take measures to enhance the skid resistance.…”

Section: Experiments Experimental Considerationsmentioning

confidence: 99%

Safe and Eco-Friendly Haze-Eliminating Pavement Coating

Zhang

Wang

et al. 2014

AMR

View full text Add to dashboard Cite

show abstract

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

2016

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The fast development of photoactivation for cancer treatment provides an efficient photo-therapeutic strategy for cancer treatment, but traditional photodynamic or photothermal therapy suffers from the critical issue of low in vivo penetration depth of tissues. As a non-invasive therapeutic modality, sonodynamic therapy (SDT) can break the depth barrier of photoactivation because ultrasound has an intrinsically high tissue-penetration performance. Micro/nanoparticles can efficiently augment the SDT efficiency based on nanobiotechnology. The state-of-art of the representative achievements on micro/nanoparticle-enhanced SDT is summarized, and specific functions of micro/nanoparticles for SDT are discussed, from the different viewpoints of ultrasound medicine, material science and nanobiotechnology. Emphasis is put on the relationship of structure/composition-SDT performance of micro/nanoparticle-based sonosensitizers. Three types of micro/nanoparticle-augmented SDT are discussed, including organic and inorganic sonosensitizers and micro/nanoparticle-based but sonosensitizer-free strategies to enhance the SDT outcome. SDT-based synergistic cancer therapy augmented by micro/nanoparticles and their biosafety are also included. Some urgent critical issues and potential developments of micro/nanoparticle-augmented SDT for efficient cancer treatment are addressed. It is highly expected that micro/nanoparticle-augmented SDT will be quickly developed as a new and efficient therapeutic modality which will find practical applications in cancer treatment. At the same time, fundamental disciplines regarding materials science, chemistry, medicine and nanotechnology will be advanced.

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Metal protoporphyrin‐induced self‐assembly nanoprobe enabling precise tracking and antioxidant protection of stem cells for ischemic stroke therapy

et al. 2023

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Mesenchymal stem cell (MSC)‐based therapy has provided a promising strategy for the treatment of ischemic stroke, which is still restricted by the lack of long‐term cell tracking strategy as well as the poor survival rate of stem cells in ischemic region. Herein, a dual‐functional nanoprobe, cobalt protoporphyrin‐induced nano‐self‐assembly (CPSP), has been developed through a cobalt protoporphyrin IX (CoPP) aggregation‐induced self‐assembly strategy, which combines CoPP and superparamagnetic iron oxide (SPION) via a simple solvent evaporation‐driven method. Without any additional carrier materials, the obtained CPSP is featured with good biocompatibility and high proportions of active ingredients. The SPIONs in CPSPs form a cluster‐like structure, endowing this nano‐self‐assembly with excellent T2‐weighted magnetic resonance (MR) imaging performance. Furthermore, the CoPP released from CPSPs could effectively protect MSCs by upregulating heme oxygenase 1 (HO‐1) expression. The in vivo cell tracing capacity of CPSPs is confirmed by monitoring the migration of labeled MSCs with MR imaging in a middle cerebral artery occlusion mouse model. More importantly, the sustained release of CoPP from CPSPs improves the survival of transplanted MSCs and promotes neural repair and neurobehavioral recovery of ischemic mice. Overall, this work presents a novel dual‐functional nanoagent with an ingenious design for advancing MSC‐based therapy.

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Preparation of Superparamagnetic Gold Nanocomposites with Different Diameters and Their Imaging and Therapy Applications

Cited by 7 publications

References 11 publications

Safe and Eco-Friendly Haze-Eliminating Pavement Coating

Safe and Eco-Friendly Haze-Eliminating Pavement Coating

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

Metal protoporphyrin‐induced self‐assembly nanoprobe enabling precise tracking and antioxidant protection of stem cells for ischemic stroke therapy

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