Preparation of Thermodesorption Tube Standards: Comparison of Usual Methods Using Accuracy Profile Evaluation

Abstract

In order to quantify organic impurities in gas produced from renewable sources, thermal desorption coupled with GC-MS or GC×GC-MS is very useful. However, the preparation of the standard tubes appears not to be trivial. For that, different strategies, based on commercial setups, have been developed. The goal of this study was to compare the classical manual deposit of a liquid standard solution with other commercial methods such as gas stream assisted deposit and vaporization followed by adsorption assisted by gas stream. A standard mixture of 48 compounds from different families was used for the comparison of the performances of the three strategies using the accuracy profile methodology. A global validation score was attributed to each strategy as well as a score according to family of compounds and boiling point range, in order to provide a detailed comparison of the techniques. On the set of studied molecules, commercial setups were found to be more efficient than the manual deposit.

Hyphenation of Thermodesorption into GC × GC-TOFMS for Odorous Molecule Detection in Car Materials: Column Sets and Adaptation of Second Column Dimensions to TD Pressure Constraints

“…These samples were prepared by depositing a droplet of standard at the top of a sampling tube, assisted by a gas stream, using the Calibration Solution Loading Rig (CSLR) from Markes International (Bridgend, UK). This method previously achieved a reliable preparation of standard tubes, as well as quantitation for these 48 compounds for a 10 ng deposit, with a limit of detection of the order of 0.1-1 ng [33].…”

Determination and Validation of Tiaprofenic Acid in Human Plasma: A Detailed LC-MS/MS-Based Analysis Following ICH M10 Guidelines and the Accuracy Profile Approach

“…The accuracy pro le approach, a statistical tool, plays a pivotal role in ensuring the precision and accuracy of bioanalytical methods [9][10]. It provides a systematic means to assess the reliability of analytical results by establishing con dence intervals around the measured concentrations [11]. This approach helps quantify the degree of accuracy and precision that can be expected when using the validated method [12].…”