Preparation of tritium‐labelled gibberellin GA<sub>3</sub> at high specific activity

Ayrey, G.; Chapman, John

doi:10.1002/jlcr.2580160611

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1981

1983

Publication Types

Select...

Article4

Book1

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 5 publications

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Partial synthesis of tritium‐labelled gibberellin‐A₃

Lischewski

Adam

Liebisch

et al. 1982

Labelled Comp Radiopharmac

View full text Add to dashboard Cite

The epimeric gibberellin-A 7-aldehydes 1 and 2 were silylated, enolised with KH and 3-labelled with -3 H20 to give after desilylation the tritium-labelled epimeric gibberellin-A ?-aldehydes 2 and 2. Subsequent acetylation, oxidation and deacetylation afforded [ 6-3H] gibberellin-A3 (6) and [ 6-3H]6-epi-gibbercllin-A provides a convenient method for the preparation of [ 6-3H] GA3 of high specific radioactivity.

show abstract

Partial synthesis of tritium‐labelled gibberellin‐A₃

Lischewski

Adam

Liebisch

et al. 1982

Labelled Comp Radiopharmac

View full text Add to dashboard Cite

show abstract

Preparation of [15‐³h] gibberellin‐A₃

Lischewski

Adam

1982

Labelled Comp Radiopharmac

View full text Add to dashboard Cite

SUMMARYThe cyclobutane compounds 2, 2, 4 or 5, which represent in position45 functionalized gibberellin derivatives, reacted with ' H 2 0 under mild alkaline conditions i n a retroaldol-like cleavage to give diacetyl[l 5-3H] gibberellin-A 7-aldehyde (6) and the isomeric compound 2.diacetyl-GA 7-aldehyde (1) was irradiated with UV-light in b e n~e n e /~H~O to form diacetyl [I5 ~x-~H] GA3-7-aldehyde (6a). rellin-A3(€l).In respect of a second possibility of 15-tritiation, 3- 3-Oxidation and deacetylation of 6 afforded [15-3H] gibbe-

show abstract