Preparation of two-dimensional magnetic molecularly imprinted polymers based on boron nitride and a deep eutectic solvent for the selective recognition of flavonoids

Abstract

Two-dimensional (2D) boron nitride (BN) were developed as a 2D scaffold material in preparation of magnetic molecularly imprinted polymers (MMIPs).

Deep Eutectic Solvents as Extraction Media for Valuable Flavonoids from Natural Sources

“…The extractions might not have the collection of a compound as the end goal. Many aimed at providing better analytical methods through the use of DES [11][12][13][14], while others attempted the creation of a substrate for several reactions or subsequent extractions (through systems constructed with the aid of DES) [15][16][17].…”

Development and applications of deep eutectic solvent derived functional materials in chromatographic separation

“…The most commonly used method for preparing DES in literature reports is heating, mixing the two components uniformly, stirring and heating at 80-100 • C until a transparent and uniform solution is formed, and a known amount of water was added when necessary. Row et al introduced the heating method of DES: using caffeic acid, ChCl, and ethylene glycol (EG) at different molar ratios by stirring the mixture in a sealed glass vial at 80 • C until a homogeneous and clear liquid formed [28]. In Chen's study, the DESs were formed by heating different HBDs (lactic acid, malonic acid, dl-malic acid, l-(+)-tartaric acid, glycerol, EG, 1,2-butanediol, 1,3butanediol, acetamide, methylurea, N,N'-dimethylurea, urea) and HBA/ChCl to 80 • C at different molar ratio (1:1, 1:2, 1:3, 1:4) with constant stirring until a homogeneous liquid formed (∼30 min) [18].…”

Sample Preparation Using Molecularly Imprinted Polymers

“…In the same way, the use of a 2D boron nitride (BN) scaffold dispersed in the polymerization mixture in the presence of Fe3O4 NPs allowed to produce MIP NPs with a binding surface of 50 instead of 30 m 2 /g without the BN scaffold. 107 Wang et al recently compared different polymerization methods to produce a MIP for capsaicin such as bulk, precipitation polymerization, that give rise to non magnetic particles, and surface imprinting technology based on silanized Fe3O4 NPs, showing that the latest possess the best affinity and adsorption capacity. 171 At last, to prepare a HRP-MIP, boronic acid was grafted on Fe3O4 NPs covered by a porous TiO2 layer instead of a silica layer before the polymerization with dopamine in order to improve the specific surface area of the sorbent, since the surface of Fe3O4@TiO2 is much rougher, which is beneficial to offer more binding sites.…”

“…94 In most of the cases, 5-100 mg of particles are dispersed in the samples. The ratio between the amount of MIP particles and the volume of the sample, that has only been optimized in some cases, 68,180 can be lower than 1, 32,33,44,94,143,158,169,179 between 1 and 10, 45,50,58,59,61,64,65,89,98,106,107,111,114,117,147,154,155,[163][164][165]170,177,178,185 or up to 50 34,66,69,144,149,168,174,181,188 and even 250 mg/mL. 43 Environmental waters were filtered 172 or directly put in contact with the MIP particles for the extraction of target analytes.…”