Preparation of ultra-long stable ovalbumin/sodium carboxymethylcellulose nanoparticle and loading properties of curcumin

Niu, Fuge; Hu, Demei; Gu, Feina; Du, Yixuan; Zhang, Bin; Ma, Shuang; Pan, Weichun

doi:10.1016/j.carbpol.2021.118451

Cited by 37 publications

(30 citation statements)

References 24 publications

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“…This may be because of the presence of many suspended undissolved curcumin particles in an aqueous solution that did not completely precipitate due to the short time. When Niu et al ( 16 ) used ultra-long stable ovalbumin/carboxymethyl cellulose nanoparticles loaded with curcumin, the solubility of curcumin loaded with nanoparticles increased by about 21,000 times than that of curcumin / aqueous solution, while the DPPH· scavenging ability increased by about 30 times. Therefore, the result showed that curcumin emulsion can not only greatly improve the dispersion and stability of curcumin, but also significantly improve its functional properties.…”

Section: Resultsmentioning

confidence: 99%

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Emulsions stabilized by cellulose-based nanoparticles for curcumin encapsulations: In vitro antioxidant properties

Zhang

Liu

et al. 2022

Front. Nutr.

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To improve the dispersity and antioxidant properties of curcumin, curcumin emulsions covered with cellulose particles (CP) with different structures were successfully prepared, and the structural characteristics, stability, and antioxidant properties of emulsions were investigated. The results showed that the CP obtained by increasing the hydrolysis time had smaller particle size, better water dispersion, and interfacial adsorption capacity. The encapsulation efficiency of curcumin in emulsion stabilized by cellulose particle hydrolyzed for 10 h can reach about 80%. After 9 days, all emulsions showed good stability, and no obvious creamed layer was observed. Compared to cellulose particles hydrolyzed for 2 h (CP2), emulsions stabilized by cellulose particles hydrolyzed for 6 h (CP6) and 10 h (CP10) exhibited better stability and free fatty acid (FFA) release. Meanwhile, the DPPH scavenging activity of curcumin emulsion stabilized by CP significantly increased with increasing the hydrolysis time and was much higher than that of pure emulsion and curcumin/water due to the higher solubility (1,455 times compared with curcumin/water solution) of curcumin, and these results could provide useful data for the stability and encapsulation of curcumin.

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Section: Resultsmentioning

confidence: 99%

“…The DPPH radical scavenging activity of the sample was determined using the method described in the literature ( 15 , 16 ). The DPPH working solution was prepared by dissolving the DPPH reagent in ethanol with a concentration of 0.1 mm.…”

Section: Methodsmentioning

confidence: 99%

Emulsions stabilized by cellulose-based nanoparticles for curcumin encapsulations: In vitro antioxidant properties

Zhang

Liu

et al. 2022

Front. Nutr.

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“…The alteration of the zeta potential by the curcumin loading gives idea about an electrostatic interaction between curcumin and ovalbumin. In a study conducted by Niu et al (2021), similar interaction was determined between nanoparticles prepared with ovalbumin and sodium carboxymethylcellulose complex. In another research in which curcumin loaded PLA (polylactic acid) nanoparticles were fabricated, the presence of curcumin in the nanoparticles reduced the negative zeta potential value from -36.18 mV to -1.12 mV (Rachmawati et al, 2016).…”

Section: Encapsulation Efficiency Particle Size and Zeta Potentialmentioning

confidence: 93%

Fabrication and characterization of curcumin loaded ovalbumin nanocarriers and bioactive properties

2022

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In this study, curcumin loaded ovalbumin nanoparticles (CONPs) were fabricated at optimized processing conditions and compared with the neat ONPs. The particles were characterized for molecular, thermal, antimicrobial, and antioxidant properties. The particle size values varied from 45.64 nm to 138.14 nm and the encapsulation efficiency of the CONP was 24%. SEM images indicated that ONPs and CONPs had spherical shapes and the particle diameters and size distributions were in accordance with the DLS measurement results. Fabrication of CONPs provided better (P < 0.05) inhibition on test pathogens as compared to pure curcumin, which demonstrates that particle size reduction of curcumin positively influenced its antibacterial efficiency. It was also clear that nanoencapsulation of curcumin significantly (P < 0.05) increased its antioxidant activity, suggesting that the curcumin/ovalbumin nanoencapsules could achieve similar antioxidant effect at much lower curcumin concentrations. FTIR results showed that curcumin was entrapped inside the ovalbumin nanocarriers successfully. According to DSC measurements, the melting temperature of ovalbumin did not change by curcumin encapsulation. In conclusion, the results suggested that ONPs could be an available carrier for encapsulation of curcumin at nano scale and had the potential to be used in the food industry and other bioactive delivery systems.

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“…The assessment method of DPPH scavenging capacity was slightly modified from Niu et al 21 The samples and DPPH-ethanol solution (0.05 × 10 −3 mol L −1 ) were mixed in a volume ratio of 1:1 (v/v) and interacted in the dark for 30 min. Ethanol was used as a blank.…”

Section: Antioxidant Activity Measurement Dpph Scavenging Activity Of...mentioning

confidence: 99%

Encapsulation of curcumin in soluble soybean polysaccharide‐coated gliadin nanoparticles: interaction, stability, antioxidant capacity, and bioaccessibility

et al. 2022

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BACKGROUND: Gliadin nanoparticles are used as a delivery system for active substances because of their amphiphilicity and bioavailability. However, they are susceptible to destabilization by external agents. In this study, gliadin nanoparticles stabilized by soluble soybean polysaccharide (SSPS) were prepared by antisolvent precipitation. Formed stable complex nanoparticles were applied to protect and deliver curcumin (Cur). RESULTS: Gliadin/SSPS nanoparticles with the smallest particle size (196.66 nm, polydispersity index < 0.2) were fabricated when the mass ratio of gliadin to SSPS was 1:1 at pH 5.0. SSPS-stabilized gliadin nanoparticles had excellent stability at pH 3.0-8.0, 0.02-0.1 mol L −1 NaCl and at 90 °C heat. Gliadin/SSPS nanoparticles were used to encapsulate the Cur. The encapsulation efficiency of the Cur-loaded gliadin/SSPS nanoparticles was 84.59%. Fourier transform infrared spectroscopy and fluorescence spectrophotometry showed that the main forces were hydrogen bonds, electrostatic interactions and hydrophobic interactions between gliadin and SSPS. The X-ray diffraction patterns exhibited that the crystalline form of Cur converted to an amorphous substance. The retention rates of Cur-loaded gliadin/SSPS nanoparticles reached 79.03%, 73.43% and 87.92% after ultraviolet irradiation for 4 h, heating at 90 °C and storage at 25 °C for 15 days, respectively. Additionally, simulated digestion demonstrated that the bioavailability of gliadin/SSPS-Cur nanoparticles was four times higher than that of free Cur.CONCLUSION: This study showed that SSPS improved the stability of gliadin nanoparticles. Gliadin/SSPS nanoparticles have the function of loading and delivering Cur.

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Preparation of ultra-long stable ovalbumin/sodium carboxymethylcellulose nanoparticle and loading properties of curcumin

Cited by 37 publications

References 24 publications

Emulsions stabilized by cellulose-based nanoparticles for curcumin encapsulations: In vitro antioxidant properties

Emulsions stabilized by cellulose-based nanoparticles for curcumin encapsulations: In vitro antioxidant properties

Fabrication and characterization of curcumin loaded ovalbumin nanocarriers and bioactive properties

Encapsulation of curcumin in soluble soybean polysaccharide‐coated gliadin nanoparticles: interaction, stability, antioxidant capacity, and bioaccessibility

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