Preparation of vitamin E microemulsion possessing high resistance to oxidation in air

Chiu, Y.C.; Yang, Wen-Tung

doi:10.1016/0166-6622(92)80253-x

Cited by 43 publications

(16 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A particularly attractive possibility is that of using ME to enhance the efficacy of molecularly solubilized, hydrophobic, biologically active compounds by providing a readily controlled, stable medium for the solubilized components, together, perhaps, with protection against degradative reactions (5).…”

mentioning

confidence: 99%

Formation and investigation of microemulsions based on jojoba oil and nonionic surfactants

Shevachman

Shani

Garti

2004

J Americ Oil Chem Soc

View full text Add to dashboard Cite

The properties of jojoba oil make it uniquely suited as a raw material for the cosmetics industry. Water-based, thermodynamically stable preparations of jojoba oil are essential in many formulations. New microemulsions were prepared based on jojoba oil and different nonionic surfactants, namely polyoxyethylene-(ethylene oxide) 10 -oleyl alcohol (Brij 96V) and ethoxylated sorbitan esters (Tweens). The effects of the surfactants and of primary alcohols as cosurfactants on the isotropic regions of the phase diagram were elucidated. It was found that, up to a certain cosurfactant chain length, the isotropic region expanded considerably as chain length increased. The size of the isotropic region also increased as a function of the ethylene glycol content of the aqueous phase in microemulsions based on ethoxylated alcohol but shrank when ethylene glycol was included in microemulsions prepared with ethoxylated sorbitan esters. Secondary structural phase transitions from water-in-oil to bicontinuous and to oil-in-water structures (as determined by measuring conductivity and viscosity) were found to be related to jojoba oil content. Dynamic light scattering and small angle X-ray scattering studies established that incorporation of jojoba oil into Brij 96V micelles caused micellar transformation from elongated to spherical droplets and a decrease in the aggregation number.Jojoba liquid wax (also called jojoba oil) is a stable, highly lipophilic, non-toxic "oily" material obtained from the seeds of the desert plant jojoba (Simmondsia chinensis) (Fig. 1). This unique oil differs from common vegetable oils and animal fats in that it is composed mainly (97%) of linear long-chain esters, which are characteristic components of waxes. More than 80% of these are esters of C 18 -, C 20 -, C 22 -, and C 24 -chain monounsaturated alcohols and acids (1).Jojoba wax resists oxidation even at elevated temperatures and can remain chemically unchanged for years. Owing to its excellent ability to penetrate the skin and high resistance to oxidation, jojoba wax is widely used as a component in cosmetics. Its derivatives have potential applications in a variety of commercial fields, including pharmaceuticals and lubrication (1). Numerous recent studies have demonstrated the feasibility of incorporating jojoba as an oil phase in formulas containing active compounds to enhance the efficacy of topical drugs (2,3).The growing interest in microemulsions (ME) for cosmetic and pharmaceutical applications is linked to their physicochemical properties-thermodynamic stability, spontaneous formation, clear appearance, low viscosity, and high solubilization capacity (4). A particularly attractive possibility is that of using ME to enhance the efficacy of molecularly solubilized, hydrophobic, biologically active compounds by providing a readily controlled, stable medium for the solubilized components, together, perhaps, with protection against degradative reactions (5).The use of alcohols as cosurfactants in the preparation of ME has a long history. Alcoho...

show abstract

mentioning

confidence: 99%

Formation and investigation of microemulsions based on jojoba oil and nonionic surfactants

Shevachman

Shani

Garti

2004

J Americ Oil Chem Soc

View full text Add to dashboard Cite

show abstract

“…Among them is the delivering of genes into the cells (Gupta et al, 2004), with the aim of treatment of disease or diagnosis (Pedersen et al, 2006, Peng et al, 2006, Xu et al, 2011, Rossi et al, 2006, Santra et al, 2005, targeting cancer cell (Tao et al, 2011, Lu et al, 2008, Reithofer et al, 2011, act as vaccine (Sun et al, 2009, Mumper & Cui, 2003, biocatalyss (Stamatis & Xenakis, 1999, Zoumpanioti et al, 2010, Blattner et al, 2006, cosmetics (Chiu & Yang, 1992, Förster et al, 1995, Valenta & Schultz, 2004, Teichmann et al, 2007 or changing the genetic to improve the performance of the targeted cells , Courrier et al, 2004.…”

Section: Applications In Biological and Health Sciencesmentioning

confidence: 99%

Microemulsions - A Brief Introduction

Najjar¹

2012

Microemulsions - An Introduction to Properties and Applications

View full text Add to dashboard Cite

“…12,13 Polymeric and oligomeric surfactants are superior to monomeric surfactants in forming large size of aggregates 14,15 and in stabilizing the shapes against changes in the circumstances. 16,17 The polymeric surfactants have such benign nature environmentally so that those have been utilized as foodadditives, 18,19 dispersing agents for cosmetics, 20,21 and drug carriers. 22,23 The surfactants are usually amphiphilic copolymers such as block, graft, and random copolymers.…”

mentioning

confidence: 99%

Control of Micellar Size and Critical Micelle Concentration for “Nonamphiphilic” Poly(vinyl phenol)-block-Polystyrene Diblock Copolymers

Yoshida

2003

Polym J

View full text Add to dashboard Cite

ABSTRACT:Control of micellar size and cmc was studied for nonamphiphilic poly(vinyl phenol)-block-polystyrene diblock copolymers (PVPh-b-PSt) in the micellization by 1,4-butanediamine (BDA). The micellization was explored for the copolymers with Mn(PSt blocks) = 20 K, 35 K, 75 K, and 125 K, holding the PVPh block length constant (Mn(PVPh blocks) = 10 K), in order to investigate effect of the PSt block length on the size of micelles. Dynamic light scattering demonstrated that the copolymers with longer PSt blocks formed larger micelles, although the copolymers had a slight difference in the unimer size. The copolymers had the transition from the unimers to the micelles at the same BDA concentration, indicating that the cmc of the copolymers was independent of the PSt block length. The PVPh block length had effects not only on the micellar size but also on the cmc. The copolymers with longer PVPh blocks showed the transition at lower BDA concentration. When the copolymers had almost the same unit ratios of VPh to St, the copolymer with larger molecular weight formed larger micelles at lower BDA concentration. The size of micelles and the cmc were also manipulated by the mixed ratio of the copolymers with different block length.KEY WORDS Poly(vinyl phenol)-block-Polystyrene (PVPh-b-PSt) / Nonamphiphilic Diblock Copolymers / Micelles / Unimers / Hydrodynamic Radius / Critical Micelle Concentration / Block Length / Surfactants are of great importance in various fields of coloring, 1, 2 coating, 3-5 adhesion, 6, 7 water purification, 8 paper manufacturing, 9, 10 food processing, 11 and drug delivery. 12, 13 Polymeric and oligomeric surfactants are superior to monomeric surfactants in forming large size of aggregates 14,15 and in stabilizing the shapes against changes in the circumstances. 16,17 The polymeric surfactants have such benign nature environmentally so that those have been utilized as foodadditives, 18, 19 dispersing agents for cosmetics, 20, 21 and drug carriers. 22,23 The surfactants are usually amphiphilic copolymers such as block, graft, and random copolymers. The block length of hydrophobic and hydrophilic moieties in the amphiphilic copolymers is an important factor to determine the physical properties of micelles such as the size of micelles, the critical micelle concentration, and the critical micelle temperature. 16,24 Accordingly, the block length and ratios always need to be taken into consideration in designing the amphiphilic copolymers.Recently, we have found the micelle formation from "nonamphiphilic" block copolymers consisting entirely of solvent-soluble blocks. 25 The copolymers themselves show no self-assembly into micelles, however, those form micelles through aggregation of part of the structures by interacting with additives. The nonamphiphilic copolymers should create micelles in a great variety because the molecular design of the micelles can be allowed through designing the copolymers and the additives. We attained the micelle formation for a nonamphiphilic poly(vinylphenol)-block-p...

show abstract

Preparation of vitamin E microemulsion possessing high resistance to oxidation in air

Cited by 43 publications

References 8 publications

Formation and investigation of microemulsions based on jojoba oil and nonionic surfactants

Formation and investigation of microemulsions based on jojoba oil and nonionic surfactants

Microemulsions - A Brief Introduction

Control of Micellar Size and Critical Micelle Concentration for “Nonamphiphilic” Poly(vinyl phenol)-block-Polystyrene Diblock Copolymers

Contact Info

Product

Resources

About