Preparation of water-in-oil emulsions using a hydrophobic polymer membrane with 3D bicontinuous skeleton structure

Mi, Yace; Zhou, Weiqing; Li, Qiang; Gong, Fangling; Zhang, Rongyue; Ma, Guanghui; Su, Zhiguo

doi:10.1016/j.memsci.2015.04.054

Cited by 19 publications

(13 citation statements)

References 30 publications

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“…This can be explained by dynamic interfacial tension, i.e., higher surfactant concentration increases the rate of adsorption to the fresh interface generated by drop formation and therefore reduction of interfacial tension is faster, and consequently, a smaller time for drop growth and detachment, producing smaller drops. The CV values obtained using a hydrophilic membrane to produce w/o emulsions are comparable to other studies where membrane emulsification process was adopted, but a hydrophobic membrane was utilised [4,[33][34][35]. Emulsion manufacturing using the Dispersion Cell is a batch process which means that during droplet formation surfactant will be depleted from the organic media.…”

Section: Droplet Formation Experimentssupporting

confidence: 78%

Membrane emulsification: Formation of water in oil emulsions using a hydrophilic membrane

Silva

Starov

Holdich

2017

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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It is shown that formation of water based droplets in an immiscible (i.e. oil) continuous phase can be achieved using a hydrophilic porous metal membrane without prior hydrophobic treatment of the membrane surface. This avoids the need for "health and safety approval" of typical hydrophobic treatments for the membrane, which often use chemicals incompatible with pharma or food applications. To investigate this, wetting experiments were carried out:sessile droplets were used to determine static contact angles and a rotating drum system was used to determine contact angles under dynamic conditions. In the latter case the three-phase contact line was observed between the rotating drum, water and the continuous phase used in the emulsification process; a surfactant was present in the continuous phase which, in this process, has a double function: to assist the wetting of the membrane by the continuous phase, and not the disperse phase, and to stabilize the droplets formed at the surface of the porous membrane during membrane emulsification. KeywordsMembrane surface, hydrophilic, water in oil emulsion, polyvinyl alcohol (PVA), droplets and contact angle 2

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Section: Droplet Formation Experimentssupporting

confidence: 78%

Membrane emulsification: Formation of water in oil emulsions using a hydrophilic membrane

Silva

Starov

Holdich

2017

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…Multilayer systems are characterized by 3 or more layers in a single structure to achieve a gradient of properties such as pore size (4, 43, 46, 53-54-55-56-57), pore shape (58), mineral content (24, 59, 60) or chemical cues (15, 56, 61-62-63-64-65-66-67). Multilayer scaffolds are usually designed for osteochondral repairs (15, 43, 46, 56, 57, 60), but they were also developed for cranial (67), vascular (68), human dermis (54) and tendon–bone interface (62) regeneration.…”

Section: Functionally Graded Scaffolds For Tissue Engineeringmentioning

confidence: 99%

Development of Polymeric Functionally Graded Scaffolds: A Brief Review

Lopresti

Scaffaro

Sutera

et al. 2016

Journal of Applied Biomaterials & Functional Materials

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Over recent years, there has been a growing interest in multilayer scaffolds fabrication approaches. In fact, functionally graded scaffolds (FGSs) provide biological and mechanical functions potentially similar to those of native tissues. Based on the final application of the scaffold, there are different properties (physical, mechanical, biochemical, etc.) which need to gradually change in space. Therefore, a number of different technologies have been investigated, and often combined, to customize each region of the scaffolds as much as possible, aiming at achieving the best regenerative performance. In general, FGSs can be categorized as bilayered or multilayered, depending on the number of layers in the whole structure. In other cases, scaffolds are characterized by a continuous gradient of 1 or more specific properties that cannot be related to the presence of clearly distinguished layers. Since each traditional approach presents peculiar advantages and disadvantages, FGSs are good candidates to overcome the limitations of current treatment options. In contrast to the reviews reported in the literature, which usually focus on the application of FGS, this brief review provides an overview of the most common strategies adopted to prepare FGS.

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“…Microgels are spherical hydrogel microparticles which can be produced by injecting an aqueous solution of gel forming monomers or pre-formed polymers through hydrophobic membrane (Mi et al, 2015). A 3D network can be formed by chemical crosslinking of monomers through condensation polymerisation (e.g.…”

Section: Integration Of Membrane Emulsification and Crosslinking Of Gmentioning

confidence: 99%

Structured microparticles with tailored properties produced by membrane emulsification

Vladisavljević

2015

Advances in Colloid and Interface Science

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This paper provides an overview of membrane emulsification routes for fabrication of structured microparticles with tailored properties for specific applications. Direct (bottom-up) and premix (top-down) membrane emulsification processes are discussed including operational, formulation and membrane factors that control the droplet size and droplet generation regimes. A special emphasis was put on different methods of controlled shear generation on membrane surface, such as cross flow on the membrane surface, swirl flow, forward and backward flow pulsations in the continuous phase and membrane oscillations and rotations. Droplets produced by membrane emulsification can be used for synthesis of particles with versatile morphology (solid and hollow, matrix and core/shell, spherical and non-spherical, porous and coherent, composite and homogeneous), which can be surface functionalised and coated or loaded with macromolecules, nanoparticles, quantum dots, drugs, phase change materials and high molecular weight gases to achieve controlled/targeted drug release and impart special optical, chemical, electrical, acoustic, thermal and magnetic properties. The template emulsions including metal-in-oil, solid-in-oil-in-water, oil-in-oil, multilayer, and Pickering emulsions can be produced with high encapsulation efficiency of encapsulated materials and narrow size distribution and transformed into structured particles using a variety of different processes, such as polymerisation (suspension, mini-emulsion, interfacial and in-situ), ionic gelation, chemical crosslinking, melt solidification, internal phase separation, layer-by-layer electrostatic deposition, particle self-assembly, complex coacervation, spray drying, sol-gel processing, and molecular imprinting. Particles fabricated from droplets produced by membrane emulsification include nanoclusters, colloidosomes, carbon aerogel particles, nanoshells, polymeric (molecularly imprinted, hypercrosslinked, Janus and core/shell) particles, solder metal powders and inorganic particles. Membrane 2 emulsification devices operate under constant temperature due to low shear rates on the membrane surface, which range from (1−10) × 10 3 s −1 in a direct process to (1−10) × 10 4 s −1 in a premix process.Keywords: Membrane Emulsification; Polymeric microsphere; Microgel; Janus Particle; Core/Shell Particle, Colloidosome. Membrane emulsificationMembrane emulsification (ME) involves preparation of emulsions by pressing a pure dispersed phase or pre-emulsified mixture of the dispersed and continuous phase through a microporous membrane under controlled injection rate and shear conditions. In direct membrane emulsification (DME), one liquid (a dispersed phase) is injected through a microporous membrane into another immiscible liquid (the continuous phase) (Nakashima et al., 1991;, which leads to the formation of droplets at the membrane/continuous phase interface ( Figure 1a). In premix membrane emulsification (PME) (Figure 1b), a pre-emulsion is pressed through the membrane (...

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Preparation of water-in-oil emulsions using a hydrophobic polymer membrane with 3D bicontinuous skeleton structure

Cited by 19 publications

References 30 publications

Membrane emulsification: Formation of water in oil emulsions using a hydrophilic membrane

Membrane emulsification: Formation of water in oil emulsions using a hydrophilic membrane

Development of Polymeric Functionally Graded Scaffolds: A Brief Review

Structured microparticles with tailored properties produced by membrane emulsification

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