Preparation of α,α-Dimethyl- and N,α,α-Trimethyl-β-cyclohexylethylamine

Zenitz, Bernard L.; Macks, Elizabeth B.; Moore, Maurice L.

doi:10.1021/ja01183a019

Cited by 10 publications

(3 citation statements)

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“…2-Amino-4-methyl-S-pentanol (EA-135). This reduction was adapted from the work of Zenitz, Macks, and Moore (7). Zinc dust (315 g., 4.8 gram-atoms) was added portionwise over 2 hours to a solution of 118 g. (0.8 mole) of 2-nitro-4-methyl-3-pentanol ( 14), 600 ml.…”

Section: Chs Ch2=c(ch2)xchrmentioning

confidence: 99%

ALIPHATIC AMINES OF PHARMACOLOGIC INTEREST. I. 2-AMINO ALKANOLS AND THEIR DERIVATIVES²

LaFORGE¹,

Whitehead²,

Keller³

et al. 1952

J. Org. Chem.

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Section: Chs Ch2=c(ch2)xchrmentioning

confidence: 99%

ALIPHATIC AMINES OF PHARMACOLOGIC INTEREST. I. 2-AMINO ALKANOLS AND THEIR DERIVATIVES²

LaFORGE¹,

Whitehead²,

Keller³

et al. 1952

J. Org. Chem.

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“…3) may permit the production of 1-(3,4-methylenedioxyphenyl)-2-nitro-l-propanol. Nitro alcohols may be reduced to the amino alcohol with zinc and sulfuric acid [124], zinc and acetic acid [125], sodium amalgam [124,125], or by catalytic hydrogenation [124][125][126].…”

Section: Precursorsmentioning

confidence: 99%

“…The conversion of amino alcohols to amines is accomplished directly by reduction with hydriodic acid [120,125] or indirectly through preparation of the l-chloro intermediate, which is then catalytically reduced [126,I27]. Phentermine (alpha, alpha-dimethylphenethylamine) and N-methylphentermine have both been synthesized from nitro alcohols [125][126]. The former drug has also been prepared by a modified Ritter reaction [44].…”

Section: Precursorsmentioning

confidence: 99%

An Evaluation of the Potential for Clandestine Manufacture of 3,4-Methylenedioxyamphetamine (MDA) Analogs and Homologs

Cason

1990

Journal of Forensic Sciences

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Encountering a novel controlled-substance analog (designer drug) has become a distinct possibility for all forensic drug laboratories. 3,4-Methylenedioxyamphetamine (MDA) in particular is a receptive parent compound for the molecular modifications which produce such homologs and analogs. The identification of these compounds, however, can prove to be an arduous task. It would be desirable to direct the focus of the identification to those compounds which are the more likely candidates for clandestine-laboratory synthesis. The process of narrowing the range of theoretical possibilities to logical choices may be enhanced by using a suitable predictive scheme. Such a predictive scheme for MDA analogs is presented based on putative Central Nervous System activity, existence or formulation of a reasonable synthesis method, and availability of the required precursors.

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α,α‐Dimethyl‐β‐Phenethylamine

Ritter¹,

Kalish

2003

Organic Syntheses

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Preparation of α,α-Dimethyl- and N,α,α-Trimethyl-β-cyclohexylethylamine

Cited by 10 publications

References 0 publications

ALIPHATIC AMINES OF PHARMACOLOGIC INTEREST. I. 2-AMINO ALKANOLS AND THEIR DERIVATIVES²

ALIPHATIC AMINES OF PHARMACOLOGIC INTEREST. I. 2-AMINO ALKANOLS AND THEIR DERIVATIVES²

An Evaluation of the Potential for Clandestine Manufacture of 3,4-Methylenedioxyamphetamine (MDA) Analogs and Homologs

α,α‐Dimethyl‐β‐Phenethylamine

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Preparation of α,α-Dimethyl- and N,α,α-Trimethyl-β-cyclohexylethylamine

Cited by 10 publications

References 0 publications

ALIPHATIC AMINES OF PHARMACOLOGIC INTEREST. I. 2-AMINO ALKANOLS AND THEIR DERIVATIVES2

ALIPHATIC AMINES OF PHARMACOLOGIC INTEREST. I. 2-AMINO ALKANOLS AND THEIR DERIVATIVES2

An Evaluation of the Potential for Clandestine Manufacture of 3,4-Methylenedioxyamphetamine (MDA) Analogs and Homologs

α,α‐Dimethyl‐β‐Phenethylamine

Contact Info

Product

Resources

About

ALIPHATIC AMINES OF PHARMACOLOGIC INTEREST. I. 2-AMINO ALKANOLS AND THEIR DERIVATIVES²

ALIPHATIC AMINES OF PHARMACOLOGIC INTEREST. I. 2-AMINO ALKANOLS AND THEIR DERIVATIVES²