Preparation of γ-PGA hydrogels and swelling behaviors in salt solutions with different ionic valence numbers

Li, Zheng; He, Guidong; Hua, Jiachuan; Wu, Maoqi; Guo, Wenjuan; Gong, Jixian; Zhang, Jianfei; Qiao, Changsheng

doi:10.1039/c6ra26419k

Cited by 45 publications

(31 citation statements)

References 55 publications

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“…The characteristic peak was observed at 3281 cm −1 with the chelate formation, which due to the existence of calcium ions. At the same time, characteristic peak of carbonyl disappeared since amino group and carboxyl group of γ‐PGA participation in the chelation reaction directly …”

Section: Resultsmentioning

confidence: 97%

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Degradation performance of polyglutamic acid and its application of calcium supplement

Zhan

Chi

et al. 2018

Polymers for Advanced Techs

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Degradable biopolymers with functional groups play a crucial role in the biomedical field. In this case, the influences of temperature and pH values on the degradation performance of poly (γ‐glutamic acid) (γ‐PGA) were fully explored by gel permeation chromatography. Further, γ‐PGA‐Ca was prepared by using calcium chloride to react with the low molecular weight γ‐PGA and characterized by Fourier transform infrared, differential scanning calorimetry test, gel permeation chromatography, atomic absorption spectrophotometric, Ca2+ release in vivo, and cytotoxicity experiments. Furthermore, Caco‐2 cell model was constructed to study the mechanism of γ‐PGA‐Ca intestinal absorption. Results indicated that low pH value and high temperature are the suitable conditions for the degradation of γ‐PGA. It also suggested that γ‐PGA‐Ca can be used as calcium supplements due to its high rate of absorption.

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Section: Resultsmentioning

confidence: 97%

“…At the same time, characteristic peak of carbonyl disappeared since amino group and carboxyl group of γ-PGA participation in the chelation reaction directly. 37,38 3.4 | GPC analysis of γ-PGA and γ-PGA-Ca…”

Section: Infrared Spectroscopic Of γ-Pga and γ-Pga-camentioning

confidence: 99%

Degradation performance of polyglutamic acid and its application of calcium supplement

Zhan

Chi

et al. 2018

Polymers for Advanced Techs

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“…Hydrogel samples were synthesized using the concentration of AgNpP according to previously-published methods [ 35 ]. The copolymer was crosslinked with –COOH and the ionized epoxy group and was loaded with Ag particles to create a matrix distribution.…”

Section: Resultsmentioning

confidence: 99%

“…The Ag-hydrogel copolymer was synthesized according to our previously published method, following a chemical method from the monomers γ-PGA and EGDE at a mass ratio of 100:40 [ 35 ]. Before cross-linking, different concentrations of nano silver solution were added drop-wise into the γ-PGA mixture.…”

Section: Methodsmentioning

confidence: 99%

Biomedical Potential of Ultrafine Ag Nanoparticles Coated on Poly (Gamma-Glutamic Acid) Hydrogel with Special Reference to Wound Healing

Wang

Dou

et al. 2018

Nanomaterials

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In wound care management, the prevention of wound infection and the retention of an appropriate level of moisture are two major challenges. Therefore, designing an excellent antibacterial hydrogel with a suitable water-adsorbing capacity is very important to improve the development of wound dressings. In this paper, a novel silver nanoparticles/poly (gamma-glutamic acid) (γ-PGA) composite dressing was prepared for biomedical applications. The promoted wound-healing ability of the hydrogels were systematically evaluated with the aim of attaining a novel and effective wound dressing. A diffusion study showed that hydrogels can continuously release antibacterial factors (Ag). Hydrogels contain a high percentage of water, providing an ideal moist environment for tissue regeneration, while also preventing contraction of the wound. Moreover, an in vivo, wound-healing model evaluation of artificial wounds in mice indicated that silver/γ-PGA hydrogels could significantly promote wound healing. Histological examination revealed that hydrogels can successfully help to reconstruct intact epidermis and collagen deposition during 14 days of impaired wound healing. Overall, this research could shed new light on the design of antibacterial silver/γ-PGA hydrogels with potential applications in wound dressing.

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“…The absence of cations in deionised water allows strong electrostatic repulsion between -COO − groups, which enables high swelling values. In buffers, the number of additional cations caused weakened electrostatic repulsion between -COO − due to the chelation between -COO − groups and cations, which presumably lead to a depressed swelling degree [25].…”

Section: Discussionmentioning

confidence: 99%

Synthesis of Hydrogels Made of Poly-γ-Glutamic Acid (γ-PGA) for Potential Applications as Probiotic-Delivery Vehicles

et al. 2020

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Numerous hydrogels made of poly-γ-glutamic acid (γ-PGA) and various cross-linkers have been explored, but only limited data on hydrogels made of γ-PGA and poly(ethylene glycol) (PEG) are available. In this study, γ-PGA, a biodegradable and edible biopolyamide, was successfully cross-linked with selected PEGs to obtain a series of hydrogels. The swelling behaviour of these hydrogels was investigated under various pH conditions. It was also found that the structure of the cross-linker (linear or branched) affected the hydrogels’ swelling behaviour. In addition, in disc diffusion assay, hydrogel discs loaded with antibiotic were tested against Staphylococcus aureus and Escherichia coli. Prolonged activity of hydrogels loaded with antibiotics in comparison to paper discs containing antibiotics was observed. Moreover, the protective effect of hydrogels on entrapped probiotic cells subjected to low pH was investigated. The hydrogel swelling ratio and amount influenced the survival rate of the protected bacteria. Considering potential biomedical applications of hydrogels, cytotoxicity was evaluated towards two cell lines, MSTO and PANC 1.

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Preparation of γ-PGA hydrogels and swelling behaviors in salt solutions with different ionic valence numbers

Abstract: In this paper, a novel poly γ-glutamic acid (γ-PGA) hydrogel was successfully synthesized by solution polymerization and ethylene glycol diglycidyl ether (EGDE) was used as crosslinker.

Cited by 45 publications

References 55 publications

Degradation performance of polyglutamic acid and its application of calcium supplement

Degradation performance of polyglutamic acid and its application of calcium supplement

Biomedical Potential of Ultrafine Ag Nanoparticles Coated on Poly (Gamma-Glutamic Acid) Hydrogel with Special Reference to Wound Healing

Synthesis of Hydrogels Made of Poly-γ-Glutamic Acid (γ-PGA) for Potential Applications as Probiotic-Delivery Vehicles

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