Preparation, physicochemical analysis and molecular modeling investigation of 2,2′-Bipyridine: β-Cyclodextrin inclusion complex in solution and solid state

Periasamy, R.; Kothainayaki, S.; Sivakumar, K.

doi:10.1016/j.molstruc.2015.07.026

Cited by 21 publications

(6 citation statements)

References 64 publications

(38 reference statements)

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“…Thus, all vibrations and bends of the βCD were shifted to lower frequencies after complexation with phenanthrene. This observation is different from the reported data [ 45 , 48 ] where all vibrations and bends of the βCD were shifted to slightly higher frequencies due to the of the “guest” molecules into the βCD cavity. This difference is due to the difference in the chemical structure of the “guest” molecules, i.e., guest molecules cause the in the vibrations and bend frequencies, but the nature of the shift (blue- or redshift) would depend upon the chemical nature of the guest molecules.…”

Section: Resultscontrasting

confidence: 99%

Pentynyl Ether of β-Cyclodextrin Polymer and Silica Micro-Particles: A New Hybrid Material for Adsorption of Phenanthrene from Water

et al. 2017

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Abstract:A new hybrid material for the removal of polycyclic aromatic hydrocarbons (PAH) from water was prepared by the polymerization of pentynyl beta-cyclodextrin (PyβCD) and silica micro-particles (SMP). Phenanthrene, being one of the important members of the PAH family and a potential risk for environmental pollution, was selected for this study. Results show that phenanthrene removal efficiency of the SMP was improved significantly after hybridization with PyβCD-polymer. Approximately 50% of the phenanthrene was removed in the first 60 min and more than 95% was removed in less than 7 h when 25 mL of the 2 ppm aqueous phenanthrene solution was incubated with the 100 mg of SMP-PyβCD-polymer material. Infrared spectroscopy and thermal gravimetric analysis show that the enhanced efficiency of the SMP-PyβCD-polymer compared to the unmodified SMP was due to the formation of the inclusion complexation of phenanthrene with the PyβCD. These results indicate that SMP-PyβCD polymers have a potential to be applied as molecular filters in water purification systems and also for waste water treatment.

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Section: Resultscontrasting

confidence: 99%

Pentynyl Ether of β-Cyclodextrin Polymer and Silica Micro-Particles: A New Hybrid Material for Adsorption of Phenanthrene from Water

et al. 2017

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“…The fact that the morphologies of the particles are quite similar to those obtained by PM and those obtained by both KND and SL does not mean that no interaction occurred between CMO and the CDs and therefore, additional studies need to be performed in order to confirm the formation of inclusion complexes. However, modifications in the shape and aspect of surface morphology have been suggested as an indication of inclusion complex formation with CDs [ 34 , 35 ].…”

Section: Resultsmentioning

confidence: 99%

Inclusion Complexes of Copaiba (Copaifera multijuga Hayne) Oleoresin and Cyclodextrins: Physicochemical Characterization and Anti-Inflammatory Activity

Pinheiro

Tavares

Silva

et al. 2017

IJMS

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Complexation with cyclodextrins (CDs) is a technique that has been extensively used to increase the aqueous solubility of oils and improve their stability. In addition, this technique has been used to convert oils into solid materials. This work aims to develop inclusion complexes of Copaifera multijuga oleoresin (CMO), which presents anti-inflammatory activity, with β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) by kneading (KND) and slurry (SL) methods. Physicochemical characterization was performed to verify the occurrence of interactions between CMO and the cyclodextrins. Carrageenan-induced hind paw edema in mice was carried out to evaluate the anti-inflammatory activity of CMO alone as well as complexed with CDs. Physicochemical characterization confirmed the formation of inclusion complex of CMO with both β-CD and HP-β-CD by KND and SL methods. Carrageenan-induced paw edema test showed that the anti-inflammatory activity of CMO was maintained after complexation with β-CD and HP-β-CD, where they were able to decrease the levels of nitrite and myeloperoxidase. In conclusion, this study showed that it is possible to produce inclusion complexes of CMO with CDs by KND and SL methods without any change in CMO’s anti-inflammatory activity.

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“…SEM is widely used to morphologically identify the formation of inclusion complexes due to the fact that such complexation usually involves changes in the surface, particle size and appearance of the parent drug [41]. When a drug is complexed within the CD cavity, the morphology of the obtained IC tends to be distinct from that of each individual component [42,43]. As shown in Figure 2, the morphological aspects of both ABAM- βCD and ABAM- HPβCD were markedly different from those of ABAM, βCD and HPβCD.…”

Section: Discussionmentioning

confidence: 99%

Inclusion Complexes of β and HPβ-Cyclodextrin with α, β Amyrin and In Vitro Anti-Inflammatory Activity

et al. 2019

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α, β amyrin (ABAM) is a natural mixture of pentacyclic triterpenes that has a wide range of biological activities. ABAM is isolated from the species of the Burseraceae family, in which the species Protium is commonly found in the Amazon region of Brazil. The aim of this work was to develop inclusion complexes (ICs) of ABAM and β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD) by physical mixing (PM) and kneading (KN) methods. Interactions between ABAM and the CD’s as well as the formation of ICs were confirmed by physicochemical characterization in the solid state by Fourier transform infrared (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), thermogravimetry (TG) and differential scanning calorimetry (DSC). Physicochemical characterization indicated the formation of ICs with both βCD and HPβCD. Such ICs were able to induce changes in the physicochemical properties of ABAM. In addition, the formation of ICs with cyclodextrins showed to be an effective and promising alternative to enhance the anti-inflammatory activity and safety of ABAM.

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Preparation, physicochemical analysis and molecular modeling investigation of 2,2′-Bipyridine: β-Cyclodextrin inclusion complex in solution and solid state

Cited by 21 publications

References 64 publications

Pentynyl Ether of β-Cyclodextrin Polymer and Silica Micro-Particles: A New Hybrid Material for Adsorption of Phenanthrene from Water

Pentynyl Ether of β-Cyclodextrin Polymer and Silica Micro-Particles: A New Hybrid Material for Adsorption of Phenanthrene from Water

Inclusion Complexes of Copaiba (Copaifera multijuga Hayne) Oleoresin and Cyclodextrins: Physicochemical Characterization and Anti-Inflammatory Activity

Inclusion Complexes of β and HPβ-Cyclodextrin with α, β Amyrin and In Vitro Anti-Inflammatory Activity

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