Preparation, physicochemical characterization, and antioxidant effects of quercetin nanoparticles

Wu, Tung Ying; Yen, Feng Lin; Lin, Liang; Tsai, Tsung-Yu; Lin, Chih‐Hsueh; Cham, Thau-Ming

doi:10.1016/j.ijpharm.2007.06.036

Cited by 322 publications

(168 citation statements)

References 48 publications

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“…The higher concentrations of PVA in the continuous phase promoted the coagulation of the nanoparticles, resulting in increased particle size. This is in contrast to the findings of Wu et al [10], that a high proportion of PVA could provide sufficient stabilization to the nanoparticles system, and reduces their particle size and size distribution.…”

Section: Effect Of Aqueous Phase Volume Of Pva Solution and Pva Concecontrasting

confidence: 99%

“…This finding is consistent with the reports from Wu et al [10], Mu and Zhong [30], Sehra and Dhake [31]. The hydrophobic portion of PVA interpenetrated into the polymer chains during nanoprecipitation, and remained trapped to the polymeric matrix of the nanoparticles.…”

Section: Effect Of Aqueous Phase Volume Of Pva Solution and Pva Concesupporting

confidence: 92%

“…Nanoparticles were prepared by the nanoprecipitaion method specified by Wu et al [10]. For basic formulation, (Batch APL) PLA and lomustine were dissolved in acetone, and was homogenized with homogenizer (Ika Labortechnik) at 19,000 rpm for 5 min.…”

Section: Preparation Of Nanoparticlesmentioning

confidence: 99%

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Critical Process Parameters Evaluation of Modified Nanoprecipitation Method on Lomustine Nanoparticles and Cytostatic Activity Study on L132 Human Cancer Cell Line

Mehrotra¹

2012

J Nanomedic Nanotechnol

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This work was focused on identification and evaluation of process parameters of modified nanoprecipitation method, for fabrication of lomustine nanoparticles, with the aim of reducing cancer cell viability at low concentration of lomustine. The parameters controlling particle size, mostly in nanosize, were solvent/nonsolvent composition and emulsification speed of homogenizer along with aqueous phase volume. This controlled particle size is below 250 nm. The stabilizer concentration controlled particle size is within 68 nm ± 0.89 to 137 ± 0.94 nm with PDI 0.06 ± 0.008 to 0.25 ± 0.001. But, the stabilizer addition mode showed more uniform size distribution with PDI 0.085 ± 0.004. Entrapment efficiency was maintained well above 47 ± 0.23%. The drug release pattern was monophasic with controlled release over 24 hrs. In the method used, drug content was affected by ratio of polymer to drug to organic solvent, as well as homogenization speed and time. Percentage viable cells of L132 human lung cancer cell line remained, were only 5% at 100 µg/ml lomustine equivalent PLA nanoparticles. ethanol as a cosolvent, homogenization speed and time were evaluated affecting the particle size, encapsulation efficiency and in vitro drug release.

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Section: Effect Of Aqueous Phase Volume Of Pva Solution and Pva Concecontrasting

confidence: 99%

Section: Effect Of Aqueous Phase Volume Of Pva Solution and Pva Concesupporting

confidence: 92%

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Critical Process Parameters Evaluation of Modified Nanoprecipitation Method on Lomustine Nanoparticles and Cytostatic Activity Study on L132 Human Cancer Cell Line

Mehrotra¹

2012

J Nanomedic Nanotechnol

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“…Significant improvement in the FRAP activity due to the nanotechnology process was also observed in the nanoparticle dietary fibre (Zhu et al, 2014) which was comparable to the chitosan nanoparticle (Pasanphan et al, 2015). While in another study, the nanotechnology process had improved the DPPH free radical inhibition of quercetin nanoparticles when the activity was found to be 883 fold higher than for its coarse particle (Wu et al, 2008). Similar remarkable free radical inhibition activity was documented by Zhang et al (Zhu et al, 2014).…”

Section: …………………………………………………………………………………………………… Introduction:-supporting

confidence: 57%

Exploring the Effect of Nanotechnology Process on Physical and Chemical Properties of Herbs: A Short Review.

Norhidayah¹,

Noriham²,

RusopM³

2017

IJAR

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“…had been extracted from the plants as their active molecule for treating various diseases. [16][17][18] From the opium popy (Papaver somniferum) morphine was isolated as a first drug by serturner. Quinine extracted from the cinchona tree (Cinchona officinalis) is used to treat malaria, and from willow bark aspirin was isolated is used for the treatment of fever.…”

Section: Review Articlementioning

confidence: 99%

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Tapadiya¹

2017

IJGP

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Natural herbs are moving from fringe to mainstream use with a increase number of population-seeking remedies and health approaches free from hazardous side effects caused by laboratory synthesize chemicals. Recently, focus has been given to utilize eco-friendly and bio-friendly natural-based products for the prevention and cure of diseases. It is documented that 80% of the world's population has belief in natural medicine, particularly plant-based drugs for their primary healthcare. Herbal drug generally introduce in the market in traditional dosage form but now different scientific approaches are being developed these days to deliver herbal medicines due to their poor rate of absorption and target specific approach. Novel drug delivery systems including nanoparticles have been developed for the effective delivery of herbal drugs. Nanoparticulate formulations such as liposomes, polymeric nanoparticles, microemulsions, proliposomes, and solid lipid nanoparticles present potential to deliver herbal medicines effectively. Because of nanotechnology, the use of herbal drug is greatly increased in recent years. In this article, we are try to elaborating the role of nanotechnology which increases the potential as well as sale of herbal drugs in global world.

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Preparation, physicochemical characterization, and antioxidant effects of quercetin nanoparticles

Cited by 322 publications

References 48 publications

Critical Process Parameters Evaluation of Modified Nanoprecipitation Method on Lomustine Nanoparticles and Cytostatic Activity Study on L132 Human Cancer Cell Line

Critical Process Parameters Evaluation of Modified Nanoprecipitation Method on Lomustine Nanoparticles and Cytostatic Activity Study on L132 Human Cancer Cell Line

Exploring the Effect of Nanotechnology Process on Physical and Chemical Properties of Herbs: A Short Review.

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