Preparation, physicochemical characterization and biological activity evaluation of some inclusion complexes containing artesunate

Circioban, Denisa; Ledeţi, Adriana; Vlase, Gabriela; Ledeți, Ionuț; Varut, Renata Maria; Pavel, Ioana Zinuca; Dehelean, Cristina

doi:10.1007/s10973-020-09763-z

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…The commonly used inclusion agent is cyclodextrin (CD). With its excellent physical properties and various taste-masking principles, it is applied in the taste-masking of ODTs, ODFs, and the latest 3D-printed ODPs (orally disintegrating printlets). , Its taste-masking principle mainly relies on the following points: (i) In the oral cavity, CD and bitter active substances form an inclusion compound whose surface possesses a strong hydration effect reducing the contact between bitter substances and taste bud receptors. , (ii) The excess and free CD compete with the drug for the bitter receptors . (iii) CD restricts the function of bitter receptors by extracting cholesterol or phospholipids. − …”

Section: Concentration-intensity Taste Maskingmentioning

confidence: 99%

“…43,44 Its taste-masking principle mainly relies on the following points: (i) In the oral cavity, CD and bitter active substances form an inclusion compound whose surface possesses a strong hydration effect reducing the contact between bitter substances and taste bud receptors. 45,46 (ii) The excess and free CD compete with the drug for the bitter receptors. 47 (iii) CD restricts the function of bitter receptors by extracting cholesterol or phospholipids.…”

Section: Insoluble Materials Coatingmentioning

confidence: 99%

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Strategies for Taste Masking of Orodispersible Dosage Forms: Time, Concentration, and Perception

Xie

et al. 2022

Mol. Pharmaceutics

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Orodispersible dosage forms, characterized as quick dissolving and swallowing without water, have recently gained great attention from the pharmaceutical industry, as these forms can satisfy the needs of children, the elderly, and patients suffering from mental illnesses. However, poor taste by thorough exposure of the drugs’ dissolution in the oral cavity hinders the effectiveness of the orodispersible dosage forms. To bridge this gap, we put forward three taste-masking strategies with respect to the intensity of time, concentration, and perception. We further investigated the raw material processing, the composition of auxiliary material, formulation techniques, and process control in each strategy and drew conclusions about their effects on taste masking.

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Section: Concentration-intensity Taste Maskingmentioning

confidence: 99%

Section: Insoluble Materials Coatingmentioning

confidence: 99%

Strategies for Taste Masking of Orodispersible Dosage Forms: Time, Concentration, and Perception

Xie

et al. 2022

Mol. Pharmaceutics

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Nanocarrier‐embedded gels: Precision drug delivery via liposomal and niosomal platforms

Trucillo,

Nebbioso,

Brancaccio

et al. 2024

Polymers for Advanced Techs

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Recent research in drug delivery has significantly advanced our knowledge of liposome and niosome‐based gels, contributing to the dynamic landscape of pharmaceutical advancements. The incorporation of these vesicular carriers into gel formulations enhanced stability, while prolonging shelf‐life and improving the bioavailability of encapsulated molecules. The synergy between liposomes/niosomes and gel matrices, facilitated by a robust gel structure, provided a protective environment, ensuring sustained drug release and prolonged stability. Liposome‐based gels proved to be versatile carriers for various therapeutic applications, demonstrating efficiency in solubilizing poorly soluble drugs and acting as potent penetration enhancers for optimal skin delivery. Today, the incorporation of liposomes in gels serves as local depots, thus being a fundamental condition for sustained and controlled drug release to optimize patient's outcomes. Insights into niosome‐based gels reveal their potential in overcoming conventional drug delivery challenges, positioning them as promising platforms for controlled and targeted drug release due to enhanced stability. Recent investigations highlight the adaptability of niosomal gels in encapsulating both hydrophobic and hydrophilic drugs, ensuring superior stability and sustained release. The tunable properties of niosomal gels also contributed to optimize bioadhesion and permeation across biological membranes. The primary objective of this work is to present the cutting‐edge findings in liposome and niosome‐based gel research, highlighting their path in modern drug delivery. These innovative solutions offer more efficient and targeted therapeutic interventions, addressing the ever‐evolving landscape of medicine.

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Cyclodextrin-based dermatological formulations: Dermopharmaceutical and cosmetic applications

Ferreira

Mascarenhas-Melo²,

Rabaça³

et al. 2023

Colloids and Surfaces B: Biointerfaces

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Preparation, physicochemical characterization and biological activity evaluation of some inclusion complexes containing artesunate

Cited by 3 publications

References 28 publications

Strategies for Taste Masking of Orodispersible Dosage Forms: Time, Concentration, and Perception

Strategies for Taste Masking of Orodispersible Dosage Forms: Time, Concentration, and Perception

Nanocarrier‐embedded gels: Precision drug delivery via liposomal and niosomal platforms

Cyclodextrin-based dermatological formulations: Dermopharmaceutical and cosmetic applications

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