Preparation, purification and morphology of polymeric nanoparticles as drug carriers

Venier-Julienne, Marie-Claire; Benoit, J.

doi:10.1016/0031-6865(95)00059-3

Cited by 71 publications

(39 citation statements)

References 14 publications

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“…Plain PLGA nanoparticles (PNPs), mannose-anchored PNPs without spacer (M-PNPs) and mannose-anchored PNPs with PEG spacer (M-PEG-PNPs) were prepared by an emulsion solvent evaporation (o/w emulsification) technique (20). Initially, specified amount of PLGA (50 mg) was dissolved with or without drug in 2 mL mixture of DMSO: DCM (30:70% v/v), acidified to pH 3.0 with acetic acid, vortexed and emulsified with 20 mL sodium cholate solution (0.02 % w/v) in a sonicator (Sonics-Vibra Cell, BC-130, Ultra sonic processor, CT, USA) at 40 W output for 60 seconds.…”

Section: Preparation Of Engineered Pnpsmentioning

confidence: 99%

Preparation, Characterization and Evaluation of Targeting Potential of Amphotericin B-Loaded Engineered PLGA Nanoparticles

Nahar

Jain

2009

Pharm Res

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Section: Preparation Of Engineered Pnpsmentioning

confidence: 99%

Preparation, Characterization and Evaluation of Targeting Potential of Amphotericin B-Loaded Engineered PLGA Nanoparticles

Nahar

Jain

2009

Pharm Res

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“…Nanoparticles are made from materials such as cadmium selenide [4,5], gold [6], silver [7], perylene [8], polystyrene [9], carbon [10,11], iron oxide [12], silica [13], titanium dioxide [14]. Some types of nanoparticles are organic-based such as latex [15], polylactic acid [16], polyglycolic acid [17] and polyalkylcyanoacrylate [18] while others are based on carbon, sulfates, nitrates [19,20], aluminum, silicon, or titanium [21].…”

Section: Introductionmentioning

confidence: 99%

In vitro tagging of embryos with nanoparticles

Fynewever

Agcaoili

Jacobson

et al. 2006

J Assist Reprod Genet

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Purpose: To develop an in vitro method for tagging embryos and to compare the development of the embryos after nanoparticles injection versus externally-applied nanoparticles derived from either polystyrene or polyacrylonitrile.Methods: Each mouse 1-cell embryo (the selected testmodel) was either: (a) injected by intracytoplasmic injection or (b) co-incubated with different nanoparticles at 37 • C, 5% CO 2 in air. The embryos were assessed after 2 and 6 days of culture.Results: Embryo development was similar for externallyapplied polystyrene nanoparticles and control (97.6 ± 2.7 versus 100.0 ± 0%) but different for polyacrylonitrile nanoparticles (90.0 ± 2.8 %) on day 2. However, the results were similar on Day 6. Injected embryos were linked to lower percent development on Day 2. Few injected embryos reached blastocyst stage on Day 6 after a brief UVfluorescence exposure.Conclusions: Tagging embryos by external polystyrenebased nanoparticles was the better method when compared with injected nanoparticles. Larger nanoparticles in micro-

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“…17,18 Oligo(ethylene oxide) monomethyl ether methacrylate was an analogue of linear poly(ethylene oxide) (PEO), which was biocompatible and prevent nanoparticle uptake by reticularendothelial system (RES). 19 The PSt-b-POEOMA-b-PSt amphiphilic block copolymer could be an excellent carrier for hydrophobic drug compared with other triblock copolymers.…”

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confidence: 99%

Polystyrene-b-poly(oligo(ethylene oxide) Monomethyl Ether Methacrylate)-b-polystyrene Triblock Copolymers as Potential Carriers for Hydrophobic Drugs

You¹,

Chang²,

Guo³

et al. 2013

Bulletin of the Korean Chemical Society

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A simple and effective method is introduced to synthesize a series of polystyrene-b-poly(oligo(ethylene oxide) monomethyl ether methacrylate)-b-polystyrene (PSt-b-POEOMA-b-PSt) triblock copolymers. The structures of PSt-b-POEOMA-b-PSt copolymers were characterized by Fourier-transform infrared spectroscopy (FTIR) and nuclear magnetic resonance ( 1 H NMR) spectroscopy. The molecular weight and molecular weight distribution of the copolymer were measured by gel permeation chromatography (GPC). Furthermore£¨the self-assembling and drug-loaded behaviours of three different ratios of PSt-b-POEOMA-b-PSt were studied. These copolymers could readily self-assemble into micelles in aqueous solution. The vitamin E-loaded copolymer micelles were produced by the dialysis method. The micelle size and core-shell structure of the block copolymer micelles and the drug-loaded micelles were confirmed by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The thermal properties of the copolymer micelles before and after drug-loaded were investigated by different scanning calorimetry (DSC). The results show that the micelle size is slightly increased with increasing the content of hydrophobic segments and the micelles are still core-shell spherical structures after drug-loaded. Moreover, the glass transition temperature (Tg) of polystyrene is reduced after the drug loaded. The drug loading content (DLC) of the copolymer micelles is 70%-80% by ultraviolet (UV) photolithography analysis. These properties indicate the micelles self-assembled from PSt-b-POEOMA-b-PSt copolymers would have potential as carriers for the encapsulation of hydrophobic drugs.

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Preparation, purification and morphology of polymeric nanoparticles as drug carriers

Cited by 71 publications

References 14 publications

Preparation, Characterization and Evaluation of Targeting Potential of Amphotericin B-Loaded Engineered PLGA Nanoparticles

Preparation, Characterization and Evaluation of Targeting Potential of Amphotericin B-Loaded Engineered PLGA Nanoparticles

In vitro tagging of embryos with nanoparticles

Polystyrene-b-poly(oligo(ethylene oxide) Monomethyl Ether Methacrylate)-b-polystyrene Triblock Copolymers as Potential Carriers for Hydrophobic Drugs

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