Preparation, spectral characterization and biological applications of Schiff base ligand and its transition metal complexes

Vinusha, H.M.; Kollur, Shiva Prasad; Revanasiddappa, H. D.; Ramu, Ramith; Shirahatti, Prithvi S.; Prasad, M. V. N. Ambika; Chandrashekar, S.; Begum, M. Yasmin

doi:10.1016/j.rechem.2019.100012

Cited by 61 publications

(26 citation statements)

References 24 publications

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“…Any changes in these conditions result in physical instabilities resulting in the making or breaking of the interactions between different amino acids to maintain structural integrity causing a denaturation [22]. Furthermore, proteins demonstrate aqueous solubility depending of various factors such as pH, temperature, isoelectric point, presence of metallic ions and hydrophobicity that are measured using modern analytical methods such as X-ray diffraction, dynamic light scattering, size exclusion chromatography, mass spectroscopy (MS), circular dichroism spectroscopy, nuclear magnetic resonance spectroscopy, and Fourier transform infrared (FTIR) spectroscopy [26]. A formulation of therapeutic proteins should consider the fact that phenomena such as association, aggregation and hydrogen bonding between amino acids occur that likely change the properties of that protein [27].…”

Section: Emphasis On the Importance Of Physicochemical Propertiesmentioning

confidence: 99%

“…Excipients and covalent modifications that are possible in order to enhance the stability of the protein should be assessed by various analytical and bioinformatic methods. Instrumentations such as UV-visible spectroscopy, fluorescence measurements, circular dichroism (CD), FTIRspectroscopy are used for the assessment of influence of excipients on the protein stability whereas differential scanning calorimetry is used for thermal stability assessment [26]. The microenvironment of the protein is determined by the UV absorption range between 250-320 nm that primarily originate because of the presence of aromatic amino acids.…”

Section: Physicochemical Properties Assessmentmentioning

confidence: 99%

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Current Status and Perspectives of Oral Therapeutic Protein and Peptide Formulations: A Review

Manu

Firdose

Jayanthi

et al. 2021

JPRI

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Medicinal formulations have evolved from the use of small molecules that act by blocking various receptors. On the contrary, therapeutic proteins are a class of medicines that have gained increased popularity owing to its low toxicity, high stability and exquisite specificity. Oral delivery of protein drugs is a very interesting but a highly challenging area of medicine that requires advancements in terms of bioavailability of oral drugs. The main objective of the present review is to provide a systematic overview of the various physiological barriers of delivery of therapeutic proteins and novel approaches available in this field in order to counter these physiological barriers. Advances in terms of inhibitors of proteases, permeation enhancers, mucoadhesives, short peptide conjugates, particulate delivery system including nanoparticles. Oral therapeutic proteins face challenges with regard to oral bioavailability, stability of the protein and reproducibility. Among the various strategies, a co-administration of permeation enhancers with protease inhibitors have proven most effective, while particulate delivery system is still under clinical studies in order to be establishes as a method. Overall, a thorough and focused research with sufficient knowledge on the structure-function relationship, substrate specificity and physiological parameters can deliver a potent therapeutic protein with high efficiency.

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Section: Emphasis On the Importance Of Physicochemical Propertiesmentioning

confidence: 99%

Section: Physicochemical Properties Assessmentmentioning

confidence: 99%

Current Status and Perspectives of Oral Therapeutic Protein and Peptide Formulations: A Review

Manu

Firdose

Jayanthi

et al. 2021

JPRI

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“…It has been proved that the cause and cure of many diseases is chelation. Many metal complexes of Schiff bases have been examined for their biological activities like antimicrobial [13], DNA interaction [14], anticarcinogenic [15], herbicidal [16], antineoplastic [17], COX-inhibitor [18], antiepileptic [19], antiviral [20], antioxidant [21] and analgesic [22]. However, important biological properties like antipathogenic [23], anticancer [24], fungicidal [25] and antidiabetic [26] are more pronounced for transition metal chelates of ethylene-1,2-diamine.…”

Section: Introductionmentioning

confidence: 99%

In-Vitro Antimicrobial Screening and Coordination Behavior of Metals Based Bidentate Compounds

Sumrra

Imran

Ibrahim

et al. 2021

J. Chil. Chem. Soc.

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By condensing ethylene-1,2-diamine with different aldehydes such as benzaldehyde, 4-chloroacetophenone and 2-chlorobenzaldeyhde within 1:2 molar ratio, resulted new series of Schiff base ligands (L 1)-(L 3) containing bidentate nitrogen atom. Their metal complexes were synthesized by coordinating the ligands with transition metals as Co(II), Cu(II), Ni(II) and Zn(II) and exhibited octahedral geometry. Their characterization was done with the help of spectral, physical and analytical analysis. Spectral and elemental analysis of all bidentate ligands and their corresponding 3d-metal chelates was consistent with their proposed structures, signifying the high purity of these compounds. For in-vitro studies, these metal complexes along their ligands were screened against the six bacterial strains; Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus and Streptococcus faecalis. Six fungal strains; Aspergillus niger, Trichophyton mentogrophytes, Epidermophyton floccosum, Trichophyton schoenleinii, Microscopum canis and Fusarium culmorum were used to study antifungal activity of the compounds. Bioactivity results exhibited that metal complexes showed higher antimicrobial potential as compared with their corresponding ligands. The enhanced activity resulted due to chelation that decreases the polarity of metal ions by complexing with bidentate ligands.

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“…(De et al, 1970) Schiff bases play crucial role as chelating agents in complexes of transition metal (Hayashi et al, 2002;Temel & Hosgoren, 2002). Various reagents (Chang et al,2019;Feig, 1949;Gili et al, 1997;Husaain et al,2019;Holloway & Melnik ,1996;Nath et al, 1974;Scott, 1939;;Sayed et al, 2010;Shaheen et al, 2019;Vinusha et al,2019) are available for the spectrophotometric determination of Manganese (II).…”

Section: Introductionmentioning

confidence: 99%

Development of Extractive Spectrophotometric Determination of Manganese (II) Using [N - (O-Methoxy Benzaldehyde)-2-Aminophenol] (NOMBAP) as an Analytical Reagent

Makhijani¹,

Sidhu²

2021

JSR

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Using analytical reagent N -(o -methoxy benzaldehyde) 2-aminophenol (NOMBAP) a feasible, sensitive and rapid spectrophotometric method has been developed for the determination of Mn (II). NOMBAP has been synthesized and characterized by elemental analysis. NOMBAP extracts Mn (II) quantitatively (99.45%) into n-Butyl alcohol from an aqueous solution of pH range 9.4 -10.7. An intense peak at 480 nm (λ max) was observed in the extract of n-Butyl alcohol. Beer's law is obeyed over the concentration range 0.5 -9.0 µg/mL for Mn (II). The molar absorptivity and Sandell's sensitivity for Mn -NOMBAP system is 62381.9 L mole -1 cm -1 and 0.0082μg cm -2 respectively. Job's Continuous Variation and Mole Ratio Method confirms that the extracted (Mn:NOMBAP) complex has composition 1:2. The average of 10 determination of 5 µg of Mn (II) in 10 cm 3 solutions was 4.999 µg, which is varied between 4.995 and 5.003 at 95% confidence limit and standard deviation is ±0.006. Interference by various ions has been studied. The proposed method is rapid, sensitive, reproducible and accurate and it has been satisfactory applied for determination of Manganese in Ore and Alloy samples)

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Preparation, spectral characterization and biological applications of Schiff base ligand and its transition metal complexes

Cited by 61 publications

References 24 publications

Current Status and Perspectives of Oral Therapeutic Protein and Peptide Formulations: A Review

Current Status and Perspectives of Oral Therapeutic Protein and Peptide Formulations: A Review

In-Vitro Antimicrobial Screening and Coordination Behavior of Metals Based Bidentate Compounds

Development of Extractive Spectrophotometric Determination of Manganese (II) Using [N - (O-Methoxy Benzaldehyde)-2-Aminophenol] (NOMBAP) as an Analytical Reagent

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