Preparation, structural and microstructural characterization of Ti–30Nb–10Ta–5Zr alloy for biomedical applications

Gudkov, Sergey V.; Simakin, Alexander V.; Konushkin, S. V.; Ivannikov, A. Yu.; Nasakina, E. O.; Shatova, L. A.; Колмаков, А. Г.; Sevostyanov, M. A.

doi:10.1016/j.jmrt.2020.11.036

Cited by 21 publications

(16 citation statements)

References 62 publications

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“…The number of cells in a state of mitosis was determined using fluorescence microscopy using in-vitro staining with the Hoechst 33342 fluorescent dye (Sigma, Saint-Louis, MO, USA) [ 31 ]. The density of the culture was assessed using the approaches developed earlier [ 32 ].…”

Section: Methodsmentioning

confidence: 99%

Additive Production of a Material Based on an Acrylic Polymer with a Nanoscale Layer of Zno Nanorods Deposited Using a Direct Current Magnetron Discharge: Morphology, Photoconversion Properties, and Biosafety

et al. 2021

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On the basis of a direct current magnetron, a technology has been developed for producing nanoscale-oriented nanorods from zinc oxide on an acrylic polymer. The technology makes it possible to achieve different filling of the surface with zinc oxide nanorods. The nanorods is partially fused into the polymer; the cross section of the nanorods is rather close to an elongated ellipse. It is shown that, with intense abrasion, no delamination of the nanorods from the acrylic polymer is observed. The zinc oxide nanorods abrades together with the acrylic polymer. Zinc oxide nanorods luminesces with the wavelength most preferable for the process of photosynthesis in higher plants. It was shown that plants grown under the obtained material grow faster and gain biomass faster than the control group. In addition, it was found that on surfaces containing zinc oxide nanorods, a more intense formation of such reactive oxygen species as hydrogen peroxide and hydroxyl radical is observed. Intensive formation of long-lived, active forms of the protein is observed on the zinc oxide coating. The formation of 8-oxoguanine in DNA in vitro on a zinc oxide coating was shown using ELISA method. It was found that the multiplication of microorganisms on the developed material is significantly hampered. At the same time, eukaryotic cells of animals grow and develop without hindrance. Thus, the material we have obtained can be used in photonics (photoconversion material for greenhouses, housings for LEDs), and it is also an affordable and non-toxic nanomaterial for creating antibacterial coatings.

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Section: Methodsmentioning

confidence: 99%

Additive Production of a Material Based on an Acrylic Polymer with a Nanoscale Layer of Zno Nanorods Deposited Using a Direct Current Magnetron Discharge: Morphology, Photoconversion Properties, and Biosafety

et al. 2021

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“…For analysis, at least 500 cells were counted on the each sample surface. The mitotic index (MI) was calculated by the formula MI = (P + M + A + T) / N × 100%, where (P + M + A + T) is the number of cells at the stage of prophase, metaphase, anaphase, and telophase, respectively, and N is the total number of analyzed cells [36].…”

Section: Cell Culturementioning

confidence: 99%

New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells

et al. 2021

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The present study a comprehensive analysis of the antibacterial properties of a composite material based on borosiloxane and zinc oxide nanoparticles (ZnO NPs). The effect of the polymer matrix and ZnO NPs on the generation of reactive oxygen species, hydroxyl radicals, and long-lived oxidized forms of biomolecules has been studied. All variants of the composites significantly inhibited the division of E. coli bacteria and caused them to detach from the substrate. It was revealed that the surfaces of a composite material based on borosiloxane and ZnO NPs do not inhibit the growth and division of mammalians cells. It is shown in the work that the positive effect of the incorporation of ZnO NPs into borosiloxane can reach 100% or more, provided that the viscoelastic properties of borosiloxane with nanoparticles are retained.

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“…SH-SY5Y cells are also interesting in that they can grow not only in monolayers but also form cell aggregates, which also take root on substrates SH-SY5Y usually used in the study of cells proliferation and differentiation in different conditions. For example, SH-SY5Y cells can spontaneously divide into one of two phenotypes, similar to "neuroblast" or "epithelial" phenotypes [65]. The SH-SY5Y cells were cultured by standard protocol in DMEM (Biolot, Moscow, Russia) supplemented with 10% fetal bovine serum (Gibco, USA) and 30 µg/mL gentamicin in a CO 2 incubator (Binder, Tuttlingen, Germany).…”

Section: Assay Of Biocompatibility With Mammalial Cellsmentioning

confidence: 99%

A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells

et al. 2021

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A method for obtaining a stable colloidal solution of silver oxide nanoparticles has been developed using laser ablation. The method allows one to obtain nanoparticles with a monomodal size distribution and a concentration of more than 108 nanoparticles per mL. On the basis of the obtained nanoparticles and the PLGA polymer, a nanocomposite material was manufactured. The manufacturing technology allows one to obtain a nanocomposite material without significant defects. Nanoparticles are not evenly distributed in the material and form domains in the composite. Reactive oxygen species (hydrogen peroxide and hydroxyl radical) are intensively generated on the surfaces of the nanocomposite. Additionally, on the surface of the composite material, an intensive formation of protein long-lived active forms is observed. The ELISA method was used to demonstrate the generation of 8-oxoguanine in DNA on the developed nanocomposite material. It was found that the multiplication of microorganisms on the developed nanocomposite material is significantly decreased. At the same time, the nanocomposite does not inhibit proliferation of mammalian cells. The developed nanocomposite material can be used as an affordable and non-toxic nanomaterial to create bacteriostatic coatings that are safe for humans.

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Preparation, structural and microstructural characterization of Ti–30Nb–10Ta–5Zr alloy for biomedical applications

Cited by 21 publications

References 62 publications

Additive Production of a Material Based on an Acrylic Polymer with a Nanoscale Layer of Zno Nanorods Deposited Using a Direct Current Magnetron Discharge: Morphology, Photoconversion Properties, and Biosafety

Additive Production of a Material Based on an Acrylic Polymer with a Nanoscale Layer of Zno Nanorods Deposited Using a Direct Current Magnetron Discharge: Morphology, Photoconversion Properties, and Biosafety

New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells

A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells

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