Preparation, structure, and properties of bis(N,N-di-n-butyldithiocarbamato)gold(III) bromide and bis(N,N-di-n-butyldithiocarbamato)gold(III) tetrabromoaurate(III)

CuII and AuIII Complexes with Glycoconjugated Dithiocarbamato Ligands for Potential Applications in Targeted Chemotherapy

“…The electronic spectra over time of AuGlu and CuGlu, as model compounds, are shown in Figure . The spectrum of AuGlu displays two intense bands at 270 nm and 312 nm related to the π*←π intra‐ligand NCS and SCS transitions, similar to 1:2 Au III dithiocarbamato analogues reported in the literature . Moreover, as chloride salt, it is stable over 72 h under physiological conditions.…”

“…The novel class of dithiocarbamato ligands explored in this study possess four hydroxy groups that can interact with the metal center, obtaining several byproducts. As a consequence, a new synthetic pathway, which permits synthesis of the [1:2]Cl compounds in good purity, was designed and optimized in this work (Scheme ) …”

“…As ac onsequence, an ew synthetic pathway,w hich permits synthesis of the [1:2]Cl compounds in good purity,w as designed and optimized in this work (Scheme1). [25,56] The reaction starts from aC H 2 Cl 2 solution containing the triphenylphosphino trihalo Au III derivative [Au III PPh 3 Cl 3 ]a sr eagent, and the desired product is formed quantitativelyu pon the addition of one equivalent of dithiocarbamato ligand, dissolved in am ethanol/water mixture (10:1 v/v)( Scheme 1, (v), Figure S1). From am echanistic point of view,i ti sp ossible to suppose that coordination of the first DTC ligand to the Au III sphere promotes the formation of an instable intermediate of the type [Au III Cl(DTC)(PPh 3 )] + .O no ne hand, the chelation of a second dithiocarbamate leads to the desired product as achloride salt.…”

“…p intra-ligand NCS and SCS transitions, similar to 1:2A u III dithiocarbamato analogues reported in the literature. [52,56,70] Moreover,a sc hloride salt, it is stable over 72 h under physiological conditions. The UV/Vis spectrum of CuGlu showsd ifferent bands.…”

X-ray structural investigations of gold compounds

“…Also rather disappointingly, the dithiolate complex `[Ph3PAu(S(CF 3 )C=C(CF3)S)2]+ C1 ' was shown to be [Ph3PC1]+[Au(S(CF3)C = C(CF3)S)2]-and thus not five-coordinate (140). The compounds reported upon were: [Au(dtc)2]+[Au(mnt)2]-( 141); the isomeric (dtc)Au(mnt) (142); [Au(dtc) 2 ]+Br -, with noncoordinated bromide ions (143); [Au(dtc) 2]+[AgBr2] -, which is not isostructural with the analogous AuBr2 compound (see Section IX) (144); Au(dtc) 3, with one bidentate and two monodentate dtc ligands (145); Br2Au(dtc), solved only in projection but shown to be isostructural with the Cu" analogue (146nc); Cu2Au(dtc),Hg2Br6, containing disordered Cu"/Au" sites (147); and Br 2Au(dtc). The structures of these compounds confirm the extremely strong tendency of Au" to square planar coordination, even when the elnpirical formulae might suggest otherwise.…”