Preparation, Surface Properties, and Therapeutic Applications of Gold Nanoparticles in Biomedicine

Panahi, Yunes; Mohammadhosseini, Majid; Nejati-Koshki, Kazem; Abadi, Azam Jafari Najaf; Moafi, Hadi Fallah; Akbarzadeh, Abolfazl; Farshbaf, Masoud

doi:10.1055/s-0042-115171

Cited by 24 publications

(23 citation statements)

References 25 publications

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“…In recent years, nanotechnology-based drug delivery systems (DDSs) have been widely developed and various nanomaterials such as graphene oxides [84], polymeric nanoparticles [85][86][87], MS [88][89][90][91] and AuNPs [92] have been investigated as drug delivery vehicles. AuNPs were the most investigated nanoparticles as DDSs, but due to their toxicity and biocompatibility issues they encountered various limits in clinical applications [93].…”

Section: Drug Deliverymentioning

confidence: 99%

Carbon quantum dots: recent progresses on synthesis, surface modification and applications

Farshbaf

Davaran

Rahimi

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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186

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Generally, carbon nanoparticles with a size of 10 nm (or less) are called carbon quantum dots (CQDs, C-dots or CD), which have created huge excitement due to their advantages in chemical inertness, high water solubility, excellent biocompatibility, resistance to photobleaching and various optical superiority. In this article, we describe the recent advancements in the area of CQDs; concentrating on their synthesis techniques, size control, surface modification approaches, optical properties, luminescent mechanism, and their applications in bioimaging, biosensing, drug delivery and catalysis.

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Section: Drug Deliverymentioning

confidence: 99%

Carbon quantum dots: recent progresses on synthesis, surface modification and applications

Farshbaf

Davaran

Rahimi

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

Self Cite

186

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“…Nanotechnology can play an important role in medicine, specifically in the early disease detection, improved diagnosis, and development of personalized treatments for chronic and infectious diseases [ 27 ]. Biocompatible AuNPs have been widely studied and applied in the diagnosis and treatment of cancer [ 28 ]. In addition, several studies indicated the intrinsic antitumor property of AuNPs that were able to selectively kill cancer cells [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Biogenic Gold Nanoparticles from Terminalia mantaly Extracts and the Evaluation of Their In Vitro Cytotoxic Effects in Cancer Cells

et al. 2020

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Scientists have demonstrated the potential of plant materials as ‘green’ reducing and stabilizing agents for the synthesis of gold nanoparticles (AuNPs) and opened new ecofriendly horizons to develop effective and less harmful treatment strategies. The current study demonstrated the use of Terminalia mantaly (TM) extracts to synthesize AuNPs with enhanced cytotoxic effects. The TM-AuNPs were synthesized at 25 and 70 °C using water (WTM) and methanolic (MTM) extracts of the leaf, root and stem/bark parts of the plant. The TM-AuNPs were characterized using UV–visible spectrophotometry, dynamic light scattering (DLS), transmission electron microscopy, energy dispersive X-ray (EDX), selection area electron diffraction (SAED) and Fourier transform infrared (FTIR) spectroscopy. Majority of the TM-AuNPs were spherical with a mean diameter between 22.5 and 43 nm and were also crystalline in nature. The cytotoxic effects of TM-AuNPs were investigated in cancer (Caco-2, MCF-7 and HepG2) and non-cancer (KMST-6) cell lines using the MTT assay. While the plant extracts showed some cytotoxicity towards the cancer cells, some of the TM-AuNPs were even more toxic to the cells. The IC50 values (concentrations of the AuNPs that inhibited 50% cell growth) as low as 0.18 µg/mL were found for TM-AuNPs synthesized using the root extract of the plant. Moreover, some of the TM-AuNPs demonstrated selective toxicity towards specific cancer cell types. The study demonstrates the potential of TM extracts to produce AuNPs and describe the optimal conditions for AuNPs using TM extracts. The toxicity of some the TM-AuNPs can possibly be explored in the future as an antitumor treatment.

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“…The risk of cancer increases after age 50 [2]. There are several strategies to inhibit and diagnosis the several steps of carcinogenesis [3][4][5][6][7]. The major approach considered is a protective strategy, which blocks the toxic matters, as well as the mutagenic effects, which accordingly prevents tumor initiation and promotion [8,9].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effect of Free and Nano-encapsulated Chrysin-Curcumin on Inhibition of hTERT Gene Expression in SW480 Colorectal Cancer Cell Line

2018

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Preparation, Surface Properties, and Therapeutic Applications of Gold Nanoparticles in Biomedicine

Cited by 24 publications

References 25 publications

Carbon quantum dots: recent progresses on synthesis, surface modification and applications

Carbon quantum dots: recent progresses on synthesis, surface modification and applications

Synthesis of Biogenic Gold Nanoparticles from Terminalia mantaly Extracts and the Evaluation of Their In Vitro Cytotoxic Effects in Cancer Cells

Synergistic Effect of Free and Nano-encapsulated Chrysin-Curcumin on Inhibition of hTERT Gene Expression in SW480 Colorectal Cancer Cell Line

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