Preparationand Characterization of pH-Sensitive Hydrogels Based on Crosslinked Maleic Anhydride-Styrene-Methyl Methacrylate Terpolymer

Abstract

In this study, the hydrogels have been synthesized by the crosslinking reactions maleic anhydridestyrene-methyl methacrylate terpolymer with N, N'-methylene-bis-acrylamide and glutaraldehyde in various crosslinker ratios. Crosslinking reactions were carried out in the presence of tetrahydrofuran as solvent at 25-50ºC for different time period, and the resulting material properties compared. The best conditions for effective crosslinking, i.e., crosslinking temperature, time and crosslinker ratios were determined for each crosslinker type. The swelling behaviour of the hydrogels was examined in Tris-buffer solutions at various pH at 37ºC. Swelling depending on pH was observed in the hydrogels. The pH-dependent swelling of hydrogels was strongly influenced by the functional group of crosslinker. The molecular structure of the hydrogels was studied by Fourier Transform Infrared Spectroscopy and their pore structure was investigated by using Scanning Electron Microscope. terpolimerinin N, N'metilenbisakrilamid ve glutaraldehitin farklı oranları ile çapraz bağlanmasıyla sentezlenmiştir. Çapraz bağlanma reaksiyonları çözücü olarak tetrahidrofuran varlığında farklı zaman periyodunda 25-50ºC aralığında gerçekleştirilmiş ve malzeme özellikleri kıyaslanmıştır. Her bir çapraz bağlayıcı tipi için çapraz bağlanma sıcaklığı, zamanı ve çapraz bağlayıcı oranı gibi etkin çapraz-bağlanma koşulları belirlenmiştir. Hidrojellerin şişme davranışı Tris tampon ortamlarda farklı pH aralığında 37ºC'de incelenmiştir. Hidrojellerin pH-duyarlı olduğu ve pH'ya bağlı şişmenin çapraz bağlayıcının fonksiyonel grubundan etkilendiği görülmüştür. Hidrojellerin moleküler yapısı Fourier Transform Infrared Spektroskopisi ile, gözenekyapısı da taramalı electron mikroskobu ile incelenmiştir.AnahtarKelimeler:Maleikanhidrit stiren metilmetakrilat terpolimer, çaprazbağlanma, N, N'-metilen-bisakrilamid, glutaraldehit, pH-duyarlı hidrojel.

Compatibilization of polyvinyl chloride ‐ polymethyl methacrylate polymer blends with maleic anhydride‐styrene‐methyl methacrylate terpolymer

“…From the Figures 7 and 8, we see that tensile strength, elongation rate, and storage modulus increase when the compatibilizer added. In a previous study showed that the tensile elongation rate was mostly determined by the shear yield of the strands between the polymers 25 . The terpolymer used preventing phase separation by acting as a bridge between polymer strands and thus increased the rate of elongation at break.…”

“…In a previous study showed that the tensile elongation rate was mostly determined by the shear yield of the strands between the polymers. 25 The terpolymer used preventing phase separation by acting as a bridge between polymer strands and thus increased the rate of elongation at break. In addition, the impact toughness corresponded to the integral of the area below the stress-strain curves can be seen in the Figure 7, where we find that by the addition of the compatibilizer there is a significant improvement in impact toughness.…”