Preparative isolation and purification of xanthohumol from hops (Humulus lupulus L.) by high-speed counter-current chromatography

Chen, Qihe; Fu, Mingzhu; Chen, Miao-miao; Liu, Jing; Liu, Xiaojie; He, Guoqing; Pu, Shou-cheng

doi:10.1016/j.foodchem.2011.10.098

Cited by 45 publications

(26 citation statements)

References 21 publications

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“…With the high-speed counter-current chromatography method being established, the extractive yield has been improved. However, it was still unable to meet the clinical needs ( Chen et al, 2012 ). Therefore, a total synthesis method for Xn was further investigated ( Khupse and Erhardt, 2007 ; Ellinwood et al, 2017 ).…”

Section: Discussion and Perspectivementioning

confidence: 99%

“…Xanthohumol (Xn; 3′-[3,3-dimethylallyl]-2′,4′,4-trihydroxy-6′-methoxychalcone), the most abundant prenylated flavonoid with 0.1–1% of dry weight in hops, can be isolated from the female inflorescences as shown in Figure 1 . It is also a constituent of beer, a major dietary source of prenylated flavonoids, where it has been found at concentrations up to 0.96 mg/L (1.95 μM) ( Chen et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

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Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.)

et al. 2018

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It has been observed that many phytochemicals, frequently present in foods or beverages, show potent chemopreventive or therapeutic properties that selectively affect cancer cells. Numerous studies have demonstrated the anticancer activity of xanthohumol (Xn), a prenylated flavonoid isolated from hops (Humulus lupulus L.), with a concentration up to 0.96 mg/L in beer. This review aims to summarize the existing studies focusing on the anticancer activity of Xn and its effects on key signaling molecules. Furthermore, the limitations of current studies and challenges for the clinical use of Xn are discussed.

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Section: Discussion and Perspectivementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.)

et al. 2018

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“…1 . Xn is also a constituent of beer, a major dietary source of prenylated flavonoids, where it has been found at concentrations of up to 0.96 mg/l (1.95 µ M) ( 5 ). In recent years, an increasing number of studies demonstrated the broad-spectrum anticancer activity of Xn in NSCLC ( 6 ), hepatocellular carcinoma ( 7 ), breast cancer ( 8 ), leukemia ( 9 ), prostate cancer ( 10 ) and glioblastoma ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Xanthohumol, a prenylated flavonoid from Hops, exerts anticancer effects against gastric cancer in�vitro

Wei

Sun

et al. 2018

Oncol Rep

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Xanthohumol (Xn), a prenylated flavonoid isolated from Hops (Humulus lupulus L.), has demonstrated potent anticancer activity in multiple types of cancer. However, the effect of Xn on gastric cancer (GC) remains unknown. The aim of the present study was to investigate the effect of Xn on GC cell proliferation, apoptosis and metastasis. It was observed that Xn decreased the viability of GC cells, with very low or no toxicity to normal gastric epithelial cells GES-1 at a concentration of 1–100 µM. The proliferation of AGS cells was inhibited by Xn, as indicated by the decreased number of EdU-positive cells. Xn treatment increased the number of apoptotic cells, downregulated the expression of Bcl-2 and upregulated the expression of Bax, suggesting induction of apoptosis. The results from the wound healing and Transwell assays indicated that Xn suppressed AGS cell metastasis. Moreover, Xn induced reactive oxygen species (ROS) overproduction and inhibited nuclear factor (NF)-κB signaling in AGS cells, which was reversed by the ROS inhibitor N-acetylcysteine (NAC). NAC suppressed the effect of Xn on the proliferation, apoptosis and metastasis of AGS cells. Taken together, these results suggest that Xn exerts anticancer effects against GC via induction of ROS production and subsequent inhibition of NF-κB signaling. Therefore, Xn may be a promising candidate treatment against GC progression.

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“…CCC is widely used in analytical and preparative separation of natural products [2][3][4][5]. The applications of CCC are mostly performed using immiscible two-phase solvent systems [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Separation of chemical constituents from three plant medicines by counter-current chromatography using a three-phase solvent system at a novel ratio

Chao

Chun

et al. 2015

Journal of Chromatography A

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Preparative isolation and purification of xanthohumol from hops (Humulus lupulus L.) by high-speed counter-current chromatography

Cited by 45 publications

References 21 publications

Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.)

Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.)

Xanthohumol, a prenylated flavonoid from Hops, exerts anticancer effects against gastric cancer in�vitro

Separation of chemical constituents from three plant medicines by counter-current chromatography using a three-phase solvent system at a novel ratio

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