The study examined the effects of insect various species such as those of Hermetia illucens, Tenebrio monitor, and Bombyx mori which have long been practiced in combination with medicinal plants and are an important alternative to modern medicine in many parts of the world. The current use of traditional pesticides since about 2010 and the characteristics of isolated biologically active molecules are presented. The natural insect products were examined or isolated from ants, bees, beetles, cockroaches, termites, bees, etc. The biological activities of these natural products derived from insects include antimicrobial, antifungal, anticancer, antiviral, antioxidant, and anti-inflammatory effects. Insect sources in animal feeds rarely distorted the relevant physicochemical variables or the sensory profile of the meat, while the fatty acid (FA) profile was the most affected variable. In fact, with proper attention, insect derivatives have great potential for the future of drug discovery of natural product, as well as for human nutritious food and for animal feeding. The inclusion of insect powder in animal feeds resulted in the prevention and treatment of disease, enhances the growth of animals and promotes the bioactive compounds in animal-based products. Due to the sustainability of its breeding, large-scale cultures of these insects seem economically viable. Insect oil and protein and chitin ingredients are widely used in cosmetics and these substances are considered as high value co-products. The major challenges associated with their use will be linked to the development of methods for separating industrial-derived materials.