2020
DOI: 10.1080/21645515.2020.1809267
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Preparatory phase for clinical trials of COVID-19 vaccine in Nepal

Abstract: Public health data suggested a rapid rise in COVID-19-confirmed cases in Nepal along with increased deaths. There has been a wide variation in clinical outcomes of this disease. Control of this pandemic depends on the availability of vaccines or drugs for SARS-CoV-2. Thus, viral and human genetics/genomics and immunology are necessary to understand whether these factors will affect clinical trials of vaccines in Nepal.

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Cited by 4 publications
(4 citation statements)
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“…9 Despite the rapid development of different platforms for COVID-19 diagnosis, realtime quantitative polymerase chain reaction (RT-qPCR) has been the gold standard method because of reasonably high sensitivity and specificity. 7,10 Apart from the SARS-CoV-2 diagnostic purpose, the potential utility of RT-qPCR Ct values in COVID-19 severity identification/ prediction has not been studied adequately in Nepal, although there are reports coming from other parts of the world. 7,10,11 This is very important during the pandemic specially in the health care resource limited countries like Nepal to enable rationale and timely use of intensive facilities for severe patients.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…9 Despite the rapid development of different platforms for COVID-19 diagnosis, realtime quantitative polymerase chain reaction (RT-qPCR) has been the gold standard method because of reasonably high sensitivity and specificity. 7,10 Apart from the SARS-CoV-2 diagnostic purpose, the potential utility of RT-qPCR Ct values in COVID-19 severity identification/ prediction has not been studied adequately in Nepal, although there are reports coming from other parts of the world. 7,10,11 This is very important during the pandemic specially in the health care resource limited countries like Nepal to enable rationale and timely use of intensive facilities for severe patients.…”
Section: Introductionmentioning
confidence: 99%
“…7,10 Apart from the SARS-CoV-2 diagnostic purpose, the potential utility of RT-qPCR Ct values in COVID-19 severity identification/ prediction has not been studied adequately in Nepal, although there are reports coming from other parts of the world. 7,10,11 This is very important during the pandemic specially in the health care resource limited countries like Nepal to enable rationale and timely use of intensive facilities for severe patients. [6][7][8]…”
Section: Introductionmentioning
confidence: 99%
“…The World Health Organization (WHO) classified Omicron as a variant of concern on 26 November 2021, adding it to the earlier variants Alpha, Beta, Gamma, and Delta [ 4 , 5 ]. Continuous viral evolution, the lack or limited availability of vaccines, and wave after wave of outbreaks have posed significant challenges to resource-limited countries such as Nepal in responding to the pandemic [ 6 , 7 ].…”
Section: Introductionmentioning
confidence: 99%
“…It is necessary to discover effective vaccines and/or drugs to overcome this nasty pandemic (Gupta and Shah, 2021). Although vaccines provide long-term immunity against COVID-19 (Izda et al, 2020), there are still certain limitations in this regard.…”
Section: Introductionmentioning
confidence: 99%