Preparedness for healthy ageing and polysubstance use in long-term cannabis users: a population-representative longitudinal study

Prenatal cannabis exposure is associated with localized brain differences that partially mediate associations with increased adolescent psychopathology

“…Thus, our findings may reflect relatively reduced neuroinflammation in PCE participants that may begin in the intrauterine environment 29 , 30 , consistent with evidence that cannabinoids reduce the inflammatory response 31 . Alternatively, cortical mean diffusivity decreases over adolescence and restricted directional diffusion increases over adolescence 32 , and thus these results may indicate accelerated neurodevelopment with PCE, consistent with prior findings that chronic cannabis use is associated with accelerated aging 33 , possibly due to co-occurring exposure to post-combustion hydrocarbons 34 .…”