Background: Attention problems are among the most prominent behavioral deficits reported in very preterm children (below 32 wk of gestation) at school age. In this study, we aimed to elucidate the brain abnormalities underlying attention problems in very preterm children by investigating the role of abnormalities in white and gray brain matter during interference control, using functional magnetic resonance imaging (fMRI)-guided probabilistic diffusion tensor tractography. Methods: Twenty-nine very preterm children (mean (SD) age: 8.6 (0.3) y), and 47 term controls (mean (SD) age: 8.7 (0.5) y), performed a fMRI version of the Eriksen Flanker task measuring interference control. results: Very preterm children showed slower reaction times than term controls when interfering stimuli were presented, indicating poorer interference control. Very preterm children and term controls did not differ in mean activation of the cortical regions involved in interference control. However, impaired fractional anisotropy (FA) was found in very preterm children in specifically those fiber tracts that innervate the cortical regions involved in interference control. Lower FA was related to poorer interference control in very preterm children. conclusion: White matter alterations have a crucial role in the interference control problems of very preterm children at school age. i mproved perinatal care has increased survival rates of very preterm (<32 wk of gestation) infants. However, large alterations in brain development remain present throughout childhood and adolescence (1), and surviving very preterm children appear to have pervasive behavioral problems more frequently than term peers (2,3). At school age, attention problems are among the most prominent behavioral deficits in very preterm children (4,5), having a detrimental impact on school performance and social functioning.One core aspect of attention is interference control, the ability to suppress distracters that might slow the primary response (6). The brain attention network involved in interference control has been widely investigated using functional magnetic resonance imaging (fMRI) tasks including the Eriksen Flanker task (7-9), suggesting involvement of the dorsal anterior cingulate cortex (dACC), inferior and lateral prefrontal cortices, and inferior parietal cortices.This study aims to elucidate brain abnormalities underpinning attention problems in very preterm children, by investigating the role of impairments in white and gray brain matter in interference control in very preterm children and term controls. First, we examined interference control problems and potential differences in cortical activation between very preterm children and term controls using the Eriksen Flanker task adapted for fMRI. Second, by using fMRI-guided probabilistic diffusion tensor tractography, we studied potential differences between very preterm children and term controls in white matter development using values of fractional anisotropy (FA) of specifically those fiber tracts that inne...