Preparing for HIV Vaccine Trials in Nigeria: Building the Capacity of the Community and National Coordinating, Regulatory and Ethical Bodies

Okpokoro, Evaezi

doi:10.4172/2155-6113.1000260

Cited by 3 publications

(4 citation statements)

References 13 publications

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“…Some research studies previously conducted in Nigeria, such as the failed Pfizer trials of 1996, lacked the required IRB regulatory approvals and documented evidence of informed consent [11–13]. Any future trials and vaccine studies, therefore, must ensure appropriate community engagement, site preparedness and adherence to the principles of Good Participatory Practice (GPP) to restore the trust of the community [14].…”

Section: Introductionmentioning

confidence: 99%

An Evaluation of Selected Populations for HIV-1 Vaccine Cohort Development in Nigeria

et al. 2016

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Development of a globally effective HIV-1 vaccine will need to encompass Nigeria, one of the hardest hit areas, with an estimated 3.2 million people living with HIV. This cross-sectional Institutional Review Board (IRB) approved study was conducted in 2009–12 at four market sites and two highway settlements sites in Nigeria to identify and characterize populations at high risk for HIV; engage support of local stakeholders; and assess the level of interest in future vaccine studies. Demographic, HIV risk data were collected by structured interviewer-administered questionnaires. Blood samples were tested on site by HIV rapid diagnostic tests, followed by rigorous confirmatory testing, subtype evaluation and testing for HBV and HCV markers in a clinical reference laboratory. Of 3229 study participants, 326 were HIV infected as confirmed by Western Blot or RNA, with a HIV prevalence of 15.4%-23.9% at highway settlements and 3.1%-9.1% at market sites. There was no observable correlation of prevalence of HIV-1 (10.1%) with HBV (10.9%) or HCV (2.9%). Major HIV-1 subtypes included CRF02_AG (37.5%); G (27.5%); G/CRF02_AG (25.9%); and non-typeable (8.9%), with 0.3% HIV-2. Univariate analysis found age, gender, marital status, level of education, and sex under substance influence as significant risk factors for HIV (p<0.001). Educating and winning the trust of local community leadership ensured high level of participation (53.3–77.9%) and willingness to participate in future studies (95%). The high HIV prevalence and high risk of HIV infection at highway settlement and mammy markets make them well suited for targeting future vaccine trials in Nigeria.

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Section: Introductionmentioning

confidence: 99%

An Evaluation of Selected Populations for HIV-1 Vaccine Cohort Development in Nigeria

et al. 2016

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“…There are plenty of methods available, among which some of them are discussed below [39][40][41][42][43].…”

Section: Bioinformatics Methods For Viral Genomicsmentioning

confidence: 99%

A Review on New Horizons of Bioinformatics in Next Generation Sequencing, Viral and Cancer Genomics

Sharma¹

2016

Int J Biomed Data Min

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Genomics and molecular biology has always been a constant source of inspiration and motivational research for worldwide researchers in field of biology and biotechnology. These two fields have always generated a huge amount of data and in order to compile and analyze those, bioinformatics came into action during last decade. Implementation of bioinformatics has a clear intention of doing all these analysis of data in efficient and fast manner in order to cut down the expensive laboratory equipment, chemicals and most precious time. Mostly genomic data is composed of sequencing results at a higher scale and that is why manual curating and handling of these data is quite difficult. Supreme aim of this review is to make awareness about bioinformatics options in cancer genomics and viral genomics apart from next generation sequencing. Next generation sequencing or high throughput sequencing has helped a lot to replace old conventional method of sequencing and with the help of recent advances in technologies. These technologies are very efficient, fast and cheaper also as compare to conventional methods. Recently used methods were also discussed under appropriate headings. Role of bioinformatics is getting bigger and bigger in management and analysis of enormous amount of biological data generated through medical, biotechnological and clinical research globally. But we still need to understand challenges and limitation of bioinformatics as well as reliability.

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“…The research pointed out that there was a paucity of high-level clinical trials in Nigeria for several reasons, including the lack of trained investigators and mentorship in implementing clinical trials at an international standard. Moreover, there was an inadequate investment and trained regulatory agencies to provide oversight (Okpokoro, Osawe & Dantong, 2013). To address these challenges, the study collaborated with the University of Ottawa to identify three regulatory agencies in Nigeria: NAFDAC (National Agency for Food and Drug Administration Control), NHREC (National Health Research Ethics Committee), and NACA (National Agency for Control of AIDS).…”

Section: Engagement With Regulatory and Supervisory Bodies For Microf...mentioning

confidence: 99%

“…These trainees also conducted a 2-day site assessment of an ongoing sero-discordant study in Jos, Nigeria, with full community engagement. The trained research team became a member of the national HIV vaccine plan implementation committee, and the supporting research laboratory updated all standard operating manuals for ISO15198 accreditation (Okpokoro, Osawe & Dantong, 2013).…”

Section: Engagement With Regulatory and Supervisory Bodies For Microf...mentioning

confidence: 99%

Microfinance and Economic Empowerment in Nigeria: A Critical Review of Impact and Sustainability

Faith Ibukun Babalola,

Noluthando Zamanjomane Mhlongo,

Moses Ikechukwu Obinyeluaku

et al. 2023

Financ. account. res. j.

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Microfinance emerges as a transformative beacon in Nigeria's journey towards economic empowerment. This paper dives into the intricate weave of microfinance within Nigeria's bustling economic narrative. Through rigorous literature analysis, we unearth the historical essence of microfinance, measure its tangible socio-economic impacts, and highlight its undeniable role in vanquishing poverty and kindling entrepreneurship. Drawing insights from a curated collection of peer-reviewed articles and empirical studies, our exploration offers a panoramic view of Nigeria's microfinance terrain. The revelations are striking. Microfinance institutions have pioneered avenues of financial inclusion, ignited entrepreneurial ventures, and steadily eroded the bastions of poverty. However, challenges like escalating loan default rates and operational inefficiencies cast long shadows. Yet, the advent of digital innovations signals hope, promising to reshape these challenges into opportunities. In summation, the paper crafts a compelling narrative: for microfinance to etch lasting imprints on Nigeria's economic canvas, it must continually reinvent, adapt, and innovate. Our recommendations are clear-cut—champion regulatory reforms, invest in capacity building, elevate financial literacy, and design financial products that echo Nigeria's diverse ethos. With microfinance as its guiding star, Nigeria's economic horizon gleams with untapped potential and promise Keywords: Microfinance, Economic Empowerment, Nigeria, Financial Landscape, Digital Innovations.

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Preparing for HIV Vaccine Trials in Nigeria: Building the Capacity of the Community and National Coordinating, Regulatory and Ethical Bodies

Cited by 3 publications

References 13 publications

An Evaluation of Selected Populations for HIV-1 Vaccine Cohort Development in Nigeria

An Evaluation of Selected Populations for HIV-1 Vaccine Cohort Development in Nigeria

A Review on New Horizons of Bioinformatics in Next Generation Sequencing, Viral and Cancer Genomics

Microfinance and Economic Empowerment in Nigeria: A Critical Review of Impact and Sustainability

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