Preparing for rotavirus vaccine introduction – A retrospective assessment of the epidemiology of intussusception in children below 2 years of age in Nepal

Abstract

This is the first study to evaluate the epidemiology of intussusception hospitalizations among children aged < 24 months in Nepal. Because the public health impact of rotavirus vaccination could be substantial in Nepal, where childhood diarrhea-related morbidity and mortality are high, this baseline knowledge of intussusception prior to introduction of rotavirus vaccine in the national immunization schedule will provide useful information for post-vaccine introduction safety monitoring.

Incidence of intussusception before and after the introduction of rotavirus vaccine in Korea

“…The risk of intussusception associated with rotavirus vaccination is an important safety issue in determining vaccine policy. Several countries have carefully monitored the occurrence of intussusception after vaccination, and others that have not yet introduced the vaccine are collecting baseline data on the incidence of intussusception before vaccination [14,15]. The pathogenesis of intussusception associated with RV is not fully elucidated.…”

“…We obtained data on infants with intussusception between 2002 and 2015 from the KNHIS database. Then, the trends in the incidence of intussusception according to the recommended ages for rotavirus vaccination (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24), and 25-34 weeks) were investigated. Moreover, we compared the mean incidence rate of intussusception for pre-vaccine licensure years 2002-2006 with that for post-vaccine licensure years 2009-2015.…”