This study investigated the magnitude and consequences of educational debt for women physicians. Methods: Participants in a women's leadership course were surveyed. Results: Of the 185 U.S. physician respondents, 152 (82%) and 85 (46%) reported past debt and current debt, respectively. A total of 164 (89%) perceived a relationship between financial stress and burnout, although burnout scores did not vary by debt magnitude. One-fifth or more reported a negative past influence of debt on each of nine aspects of professional development or well-being. Conclusion: Educational debt has negative effects on the careers and well-being of women physicians.