BackgroundTiLOOP bra has been used for over 15 years, however, evidence regarding its safety in implant‐based breast reconstruction (IBBR) for patients with breast cancer after mastectomy is still limited. We performed this meta‐analysis to evaluate its risks and benefits in IBBR comparing with other meshes.MethodsElectronic databases were searched to identify relevant studies comparing postoperative complications between TiLOOP bra and other reconstruction techniques in IBBR with or without meshes. We also compared patient satisfaction in physical well‐being between two groups. Risk ratios (RRs) and mean differences with 95% confidence interval (CI) were calculated.ResultsSeven studies representing 1203 cases were analyzed. Compared with other meshes, the use of TiLOOP bra significantly reduced the risk of infection (RR = 0.53, 95% CI, 0.32–0.86), seroma (RR = 0.21, 95% CI, 0.07–0.61), red breast syndrome (RR = 0.10, 95% CI, 0.02–0.45), and capsular contracture (RR = 0.20, 95% CI, 0.05–0.75). Patient satisfaction in physical well‐being was comparable between two groups.ConclusionsTiLOOP bra in IBBR has a favored safety profile over other meshes, which significantly reduced postoperative complication risk and did not affect patient satisfaction. Although prospective well‐designed controlled studies are still warranted, TiLOOP bra is safe and reliable at present.