Prepregnancy and Early Adulthood Body Mass Index and Adult Weight Change in Relation to Fetal Loss

Gaskins, Audrey J.; Rich‐Edwards, Janet W.; Colaci, Daniela; Afeiche, Myriam C.; Toth, Thomas L.; Gillman, Matthew W.; Missmer, Stacey A.; Chavarro, Jorge E.

doi:10.1097/aog.0000000000000478

Cited by 19 publications

(17 citation statements)

References 38 publications

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“…As both of these conditions have been linked to obesity (26), this would support the stronger effects we observed in the current duration cohort. Moreover, due to the design of his cohort, women had to retrospectively report their time-to-pregnancy.…”

Section: Discussionsupporting

confidence: 84%

Association of Fecundity With Changes in Adult Female Weight

Gaskins

Rich‐Edwards

Missmer

et al. 2015

Obstetrics &Amp; Gynecology

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Objective To evaluate whether weight change since age 18, current body mass index (BMI), and BMI at age 18 are associated with fecundity. Methods Our study included 1,950 women currently attempting pregnancy in the Nurses’ Health Study 3 (2010–2014), a prospective cohort study. Height, current weight, and weight at age 18 were self-reported on the baseline questionnaire. Every 3 to 6 months thereafter, women reported the current duration of their pregnancy attempt. Multivariable accelerated failure time models were used to estimate the time ratios and 95% confidence intervals (CI). Results For every 5 kg increase in body weight from age 18, current duration of pregnancy attempt increased by 5% (95% CI 3, 7%). Compared to women who maintained weight, the adjusted median current duration was 0.5 months shorter in those who lost weight, 0.3 months longer for those who gained 4–9.9 kg and 10–19.9 kg, and 1.4 months longer for those who gained ≥20 kg (p-trend= <0.001). The adjusted time ratio (95% CI) for a 5 kg/m2 increase in current BMI was 1.08 (1.04, 1.12). After multivariable adjustment (including adjustment for current BMI), being underweight at age 18 (BMI < 18.5) was associated with a longer current duration of pregnancy attempt compared to normal weight women (time ratio: 1.25 95% CI 1.07, 1.47); however being overweight or obese at age 18 was not associated with fecundity. Conclusions Gaining weight in adulthood, being overweight or obese in adulthood, and being underweight at age 18 were associated with a modest reduction in fecundity.

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Section: Discussionsupporting

confidence: 84%

Association of Fecundity With Changes in Adult Female Weight

Gaskins

Rich‐Edwards

Missmer

et al. 2015

Obstetrics &Amp; Gynecology

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“…Women who are obese or overweight may have an increased risk of pregnancy loss in natural and assisted conceptions, plausibly due to decrements in oocyte quality or endometrial receptivity . However, among women who were obese and undergoing infertility treatment, a recent trial found that short‐term, medically supervised weight loss made no difference in clinical pregnancy rates and suggested an increased risk of clinical pregnancy loss, contradicting earlier studies that found such interventions improved outcomes among women with obesity and infertility .…”

Section: Introductionmentioning

confidence: 93%

Recent attempted and actual weight change in relation to pregnancy loss: a prospective cohort study

Radin

Mumford

Sjaarda

et al. 2017

BJOG

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Objective To assess weight change and attempted weight loss during the 12-18 months before spontaneous conception in relation to the risk of pregnancy loss.Design Prospective cohort study.Setting United States, 2007States, -2011 Methods Women (n = 629) who were attempting pregnancy reported at baseline any weight loss attempts over the past 12 months, and their minimum and maximum weights during that time. Follow up lasted one to six menstrual cycles and throughout pregnancy. Using bodyweight measured at 4 weeks' gestation, participants were categorised as having weight loss ≥5%, weight gain ≥5%, both, or neither, over the previous 12-18 months. Log-binomial models adjusted for potential confounders. Main outcome measures Risk ratio (RR) and 95% confidence interval (CI) of pregnancy loss.Results Attempted weight loss was reported by 44% of women and actual weight loss by 11%, but neither was consistently associated with pregnancy loss. The RR for recent weight gain ≥5% was 1.65 (CI 1.09, 2.49).Conclusions Weight gain over the period spanning 12-18 months pre-conception to 4 weeks' gestation may increase the risk of pregnancy loss among fertile women with prior pregnancy losses. Attempted and actual weight loss were not associated with pregnancy loss; however, replication is needed from larger studies with data on particular weight-loss methods.

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“…Moreover, excessive weight gain during pregnancy has been associated with breastfeeding difficulties during the postpartum period 3. Weight gain during pregnancy also has an impact on gestational age-matched healthy development of the fetus and on birth weight 4. Obesity has been increasing worldwide in recent years, with a prevalence of 23.9% in Turkey 5.…”

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confidence: 99%

Factors affecting pregnancy weight gain and relationships with maternal/fetal outcomes in Turkey

Akgün

Keskin

Üstüner

et al. 2017

SMJ

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Objectives:To determine the effects of pre-pregnancy body mass index (BMI) and gestational weight gain on maternal and fetal complications, and to examine whether Turkish women achieve the recommended gestational weight gain. We also investigated the relationship between pregnancy weight gain and mode of delivery, with an examination of maternal anthropometry.Methods:A retrospective cross-sectional study was conducted on a population of 986 pregnant women between November 2011 and November 2015 at Atatürk Education and Research Hospital, Ankara, Turkey. Maternal age, BMI, monthly weight gain during pregnancy, infant birth weight, gender, and maternal and fetal adverse outcomes were evaluated.Results:The frequency of maternal complications was positively associated with elevated pre-pregnancy BMI (p<0.05), and weight gain during pregnancy was associated with parity and increased infant birth weight (p<0.05). However, no correlations were observed between mean pregnancy weight gain and maternal complications (p>0.05). The percentage of women who gained the Institute of Medicine (IOM)-recommended amount of weight was the highest in the underweight BMI group (54.1%) and the lowest in the obese BMI group (24.3%). Pregnancy weight gain exceeded IOM recommendations in the overweight (56.3%) and obese (52.5%) groups.Conclusions:While maternal weight gain during pregnancy affects neonatal body weight, higher pre-pregnancy BMI has an adverse effect on recommended weight gain during pregnancy, with increased maternal complications.

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Prepregnancy and Early Adulthood Body Mass Index and Adult Weight Change in Relation to Fetal Loss

Cited by 19 publications

References 38 publications

Association of Fecundity With Changes in Adult Female Weight

Association of Fecundity With Changes in Adult Female Weight

Recent attempted and actual weight change in relation to pregnancy loss: a prospective cohort study

Factors affecting pregnancy weight gain and relationships with maternal/fetal outcomes in Turkey

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