Prepubertal acrylamide exposure causes dose-response decreases in spermatic production and functionality with modulation of genes involved in the spermatogenesis in rats

Ivanski, Fernanda; Oliveira, Viviane Matoso de; Oliveira, Isabela Medeiros de; Araújo-Ramos, Anderson Tadeu de; Tonete, Selma Thaisa de Oliveira; Hykavei, Gabriel de Oliveira; Bargi‐Souza, Paula; Schiessel, Dalton Luiz; Martino‐Andrade, Anderson Joel; Romano, Marco Aurélio; Romano, Renata Marino

doi:10.1016/j.tox.2020.152428

Cited by 20 publications

(8 citation statements)

References 45 publications

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“…The human ESR2 gene (estrogen receptor 2) -both in the case of underexpression in adolescents and in the case of its overexpression in this segment of the population -was associated with decreased sperm quality in adults (Ivanski et al, 2020). These alterations of its expression in humans are consistent with those of an orthologous gene, Esr2, in tame and aggressive foxes (Hekman et al, 2018) during their microevolution (see Table 4).…”

Section: Resultsmentioning

confidence: 64%

A bioinformatic search for correspondence between differentially expressed genes of domestic versus wild animals and orthologous human genes altering reproductive potential

et al. 2022

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One of the greatest achievements of genetics in the 20th century is D.K. Belyaev’s discovery of destabilizing selection during the domestication of animals and that this selection affects only gene expression regulation (not gene structure) and influences systems of neuroendocrine control of ontogenesis in a stressful environment. Among the experimental data generalized by Belyaev’s discovery, there are also findings about accelerated extinction of testes’ hormonal function and disrupted seasonality of reproduction of domesticated foxes in comparison with their wild congeners. To date, Belyaev’s discovery has already been repeatedly confirmed, for example, by independent observations during deer domestication, during the use of rats as laboratory animals, after the reintroduction of endangered species such as Przewalski’s horse, and during the creation of a Siberian reserve population of the Siberian grouse when it had reached an endangered status in natural habitats. A genome-wide comparison among humans, several domestic animals, and some of their wild congeners has given rise to the concept of self-domestication syndrome, which includes autism spectrum disorders. In our previous study, we created a bioinformatic model of human self-domestication syndrome using differentially expressed genes (DEGs; of domestic animals versus their wild congeners) orthologous to the human genes (mainly, nervous-system genes) whose changes in expression affect reproductive potential, i.e., growth of the number of humans in the absence of restrictions caused by limiting factors. Here, we applied this model to 68 human genes whose changes in expression alter the reproductive health of women and men and to 3080 DEGs of domestic versus wild animals. As a result, in domestic animals, we identified 16 and 4 DEGs, the expression changes of which are codirected with changes in the expression of the human orthologous genes decreasing and increasing human reproductive potential, respectively. The wild animals had 9 and 11 such DEGs, respectively. This difference between domestic and wild animals was significant according to Pearson’s χ2 test (p < 0.05) and Fisher’s exact test (p < 0.05). We discuss the results from the standpoint of restoration of endangered animal species whose natural habitats are subject to an anthropogenic impact.

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Section: Resultsmentioning

confidence: 64%

A bioinformatic search for correspondence between differentially expressed genes of domestic versus wild animals and orthologous human genes altering reproductive potential

et al. 2022

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“…Acrylamide produces reductions in sperm production in rodents dosed in adulthood (Ivanski et al, 2020;Kalaivani et al, 2018;Kermani-Alghoraishi et al, 2010) through a mechanism involving disturbance of testosterone levels. The lowest reported LOAEL of 2.5 mg/kg/d is by Ivanski et al (2020). Kermani-Alghoraishi et al 2010 andKalaivani et al 2018 observed LOAELs of 5 and 6.5 mg/kg/d, respectively.…”

Section: Acrylamidementioning

confidence: 99%

“…Kermani-Alghoraishi et al 2010 andKalaivani et al 2018 observed LOAELs of 5 and 6.5 mg/kg/d, respectively. By application of a LOAEL to NOAEL extrapolation factor of 3, and the default factor of 100, we obtained a RfD of 8.3 rounded down to 8 µg/ kg/d from the study by Ivanski et al (2020).…”

Section: Acrylamidementioning

confidence: 99%

Combined exposures to bisphenols, polychlorinated dioxins, paracetamol, and phthalates as drivers of deteriorating semen quality

Kortenkamp

Scholze

Ermler

et al. 2022

Environment International

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“…Serum inhibin B is a member of the transforming growth factorβ superfamily in supporting cells, where high inhibin B may inhibit follicle-stimulating hormone(FSH)secretion and reduce spermatogenesis through negative feedback mechanism (Figure 4) (Chu et al, 2003). AA can impair adult male fertility by reducing spermatogenesis and inducing morphological and functional defects in spermatozoa (Ivanski et al, 2020). For females, AA can affect the estradiol level in premenopausal women and influence reproductive function by altering the secretion of sex hormones.…”

Section: Reproduc Ve Toxicitymentioning

confidence: 99%

Contaminant acrylamide in food: toxicity, detection methods, mitigation measures and risk assessment for humans

Huang¹,

Jiang²,

Yang³

et al. 2021

NRFHH

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Food safety is related to all aspects of human life, and the quality of food has a profound impact on people's lives and health. Acrylamide is a chemical pollutant produced by the Maillard reaction in baked goods such as potato chips, bread, and cookies. Studies have shown that acrylamide has neurotoxicity, carcinogenicity, reproductive toxicity, genotoxicity, and hepatosplenic toxicity in humans. However, the carcinogenicity of acrylamide in humans is still controversial, and it is unclear whether there is a significant correlation between human exposure to acrylamide and cancer incidence. This review aims to explore the latest research on the human health hazards of acrylamide and prevent or reduce the hazards of acrylamide to humans by detection methods, risk assessment, and mitigation measures to ensure people's food safety.

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Prepubertal acrylamide exposure causes dose-response decreases in spermatic production and functionality with modulation of genes involved in the spermatogenesis in rats

Cited by 20 publications

References 45 publications

A bioinformatic search for correspondence between differentially expressed genes of domestic versus wild animals and orthologous human genes altering reproductive potential

A bioinformatic search for correspondence between differentially expressed genes of domestic versus wild animals and orthologous human genes altering reproductive potential

Combined exposures to bisphenols, polychlorinated dioxins, paracetamol, and phthalates as drivers of deteriorating semen quality

Contaminant acrylamide in food: toxicity, detection methods, mitigation measures and risk assessment for humans

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