Prepubertal periodontitis

Abstract

An 11-year-old boy with clinical and radiological features of prepubertal periodontitis is presented. He had a history of recurrent upper respiratory tract infections and otitis media. Neutrophil chemotaxis was significantly reduced compared to normal. Total T- and B-lymphocyte numbers were not altered. T-lymphocyte subsets studied with monoclonal antibodies revealed that both T-helper and T-suppressor cell populations were reduced with a normal TH/TS ratio of 1.8. No significant changes were observed in the serum IgG, IgA and IgM values. Serum C3c and C4 levels were found to be elevated. These findings may contribute to the pathogenesis of prepubertal periodontitis.

Neutrophil Chemotaxis and Periodontal Status in Down's Syndrome Patients.

“…In different forms of periodontal disease (prepubertal periodontitis, juvenile periodontitis, rapidly progressive periodontitis), impaired neutrophil chemotaxis has been well demonstrated previously [29,32,33]. Severe periodontal destruction at an early age together with comparable alveolar bone loss and various degrees of impairment of the host response, are prominent features of both DS and juvenile periodontitis.…”

A combination of clinical and microbiological management of generalized aggressive periodontitis in primary teeth. A case report

“…All isolates recovered from the present patient with aggressive periodontitis and her sister were highly leukotoxic, producing a characteristic 545-bp amplicon, whereas all strains isolated from her father and mother were minimally leukotoxic. According to the literature, all leukotoxic strains comprise a single clone and are particularly abundant in Africans and their descendants 16,28,32 , such as were the members of the family reported here. In this population, the distribution might be closely related to cultural aspects and contacts among relatives 32 .…”

“…According to the literature, all leukotoxic strains comprise a single clone and are particularly abundant in Africans and their descendants 16,28,32 , such as were the members of the family reported here. In this population, the distribution might be closely related to cultural aspects and contacts among relatives 32 . In the present case of aggressive periodontitis and her relatives, however, only the patient and her sister were colonized with highly leukotoxic bacteria, a fact suggesting another source for this microorganism.…”

Papillon‐Lefèvre Syndrome. Analysis of Neutrophil Chemotaxis

“…43-48-50 It was observed that neutrophils were normal in patients with Papillon-Lefèvre syndrome.24-33 Contrary to these findings in most of the studies with the patients with PLS, the peripheral blood neutrophil Chemotaxis was depressed.162226-34 The decrease in the Chemotaxis may be due to a cell defect in the receptor located at the surface of the neutrophil.50 It has been reported that the Chemotaxis defect might be the result of deficiencies in the cellular adhesion molecules.26-50-52 Another suggested cause was an abnormality in cell adhesion which resulted from abnormalities on CDU molecules in children with generalized prepubertal Periodontitis. [2][3][4][5] In this study, we found that the Chemotaxis of neutrophils in PLS patients decreased compared to healthy controls. The neutrophil Chemotaxis defect in patients with PLS is characterized by a decrease in the cell migration toward a chemotactic factor (ZAS).…”