Prepubertal testicular tumors in China: a 10-year experience with 67 cases

Wu, Dazhou; Shen, Nanping; Lin, Xiaokun; Chen, Xiaoming

doi:10.1007/s00383-018-4366-6

Cited by 21 publications

(24 citation statements)

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“…One study focused solely on malignant tumors [ 28 ]. Thirteen studies specifically examined the prepubertal population [ 22 , 24 , 25 , 26 , 27 , 28 , 31 , 33 , 34 , 35 , 37 , 39 , 41 ]. Six articles reported on both pre- and (post)pubertal children, although the majority of their population was prepubertal [ 21 , 23 , 30 , 32 , 36 , 38 ].…”

Section: Resultsmentioning

confidence: 99%

“…Liu et al performed TSS in patients with negative STMs and typical benign characteristics on US (ultrasonographic) imaging [ 24 ]. In the study of Wu et al, normal AFP levels in combination with salvageable testicular parenchyma on US were required for considering TSS [ 25 ]. Ye et al took TSS into consideration in cases with negative STMs and other characteristics of a benign tumor, and in absence of malignancy on FSE, TSS was performed [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

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Testis Sparing Surgery in Pediatric Testicular Tumors

Kooij

Hulsker

Kranendonk

et al. 2020

Cancers

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Objective: The purpose of this review is to evaluate the outcomes of testis sparing surgery (TSS) and to investigate under which circumstances TSS can be considered a safe treatment option in pediatric patients with testicular tumors. Methods: A database search was performed in Cochrane, Pubmed, and Embase for studies that focused on TSS as treatment for testicular tumors in the pediatric population, excluding reviews and single case reports. Results: Twenty studies, describing the surgical treatment of 777 patients with testicular tumors, were included in the analysis. The majority of pediatric patients with benign germ cell tumors (GCTs) (mean age: 3.7 years) and sex cord-stromal tumors (SCSTs) (mean age: 6.6 years) were treated with TSS, 61.9% and 61.2%, respectively. No cases of testicular atrophy occurred. Four of the benign GCTs, i.e., three teratomas and one epidermoid cyst, recurred. No cases of recurrence were reported in patients with SCSTs. Of the 243 malignant GCTs (mean age: 4.2 years), only one patient had TSS (0.4%). Conclusion: TSS is a safe treatment option for prepubertal patients less than 12 years of age with benign GCTs and low grade SCSTs.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Testis Sparing Surgery in Pediatric Testicular Tumors

Kooij

Hulsker

Kranendonk

et al. 2020

Cancers

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“…Testicular epidermoid cysts can be seen in childhood as well as in adults. Wu et al [13] reported a patient with testicular epidermoid cyst who was 3 months old at diagnosis. In adults, cases are more commonly diagnosed in the 2nd and 3rd decades.…”

Section: Discussionmentioning

confidence: 99%

Epidermoid Cyst of the Testis 5-Year Follow-Up Results in Adults

Ediz¹,

İhvan²,

Kati³

et al. 2019

OJU

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Background: In this study, we aimed to share our experiences in patients with epidermoid cyst of the testis. We report the demographic and clinical characteristics and the long term results in patients with epidermoid cysts. Materials and Methods: Thirteen patients with epidermoid cyst of the testis treated between June 2000 and January 2018 were retrospectively evaluated. Ten patients with available data were included in the study. Patients' age, scrotal localization of symptoms, physical examination findings, serum tumor marker levels, pathology results and follow-up periods were recorded. Results: The current cohort consisted of 10 patients. The mean age at diagnosis was 29.7 years (range, 20 to 53 years). Eighty percent of the lesions were localized to the left hemiscrotum and 20% to the right hemiscrotum. One patient had a history of unilateral undescended testis. Serum tumor markers were normal in all patients. The mean scrotal mass lesion volume at diagnosis was 28 mm 3 (range, 13 to 51 mm 3). The mean follow-up period was 66.9 months (range, 12 to 216 months). Conclusions: Epidermoid cyst of the testis should be kept in mind, particularly in patients with lesions negative for tumor markers and radiological findings typical of epidermoid cysts. Annual follow-up is not required.

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“…En las últimas décadas, se ha reevaluado el abordaje terapéutico de las masas testiculares en niños, debido a la preponderancia de la enfermedad benigna en la etapa prepuberal (3,17,28). Dado que la presentación clínica es muy similar para todos los casos, la evaluación diagnóstica debe incluir un examen físico completo, la ecografía Doppler testicular y la medición de marcadores tumorales (gonadotropina coriónica humana subunidad beta y alfa fetoproteína séricas) (29).…”

Section: Discussionunclassified

“…No se documentó ningún caso de recurrencia, metástasis, ni atrofia (7). Por otro lado, una cohorte retrospectiva de 67 pacientes menores de 14 años tratados por tumores testiculares entre 2005 y 2015, con seguimiento a 23 meses, no registró ningún caso de recurrencia ni atrofia testicular (29).…”

Section: Discussionunclassified

Lesión quística testicular en un lactante: consideraciones diagnósticas y terapéuticas

2019

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Introducción: Los tumores testiculares prepuberales suelen ser benignos. Las lesiones quísticas constituyen un amplio diagnóstico diferencial de las masas benignas escrotales en niños. Una adecuada evaluación incluye el examen clínico, la ecografía Doppler y la medición de marcadores tumorales. Ante una fuerte sospecha clínica y radiológica de benignidad, el tratamiento de elección es la enucleación con preservación del parénquima. Objetivo: Describir el caso de un lactante con una masa quística de testículo compatible con quiste epidermoide. Discutir los aspectos clínicos, imagenológicos y terapéuticos más relevantes de las lesiones testiculares prepuberales. Presentación del caso: Un lactante ingresa por identificación de una masa testicular circunscrita no dolorosa de 1 cm de diámetro. La ecografía demuestra un quiste simple intraparenquimatoso y los marcadores tumorales son negativos. Se realiza enucleación por vía escrotal, sin complicaciones. El estudio histopatológico es compatible con un quiste epidermoide. Hubo seguimiento a 3 años sin recidiva ni atrofia testicular. Discusión y conclusión: Teniendo en cuenta que la mayoría de los tumores prepuberales de testículo son benignos, la cirugía conservadora puede considerarse una alternativa terapéutica ante una lesión circunscrita, pequeña, avascular, con marcadores tumorales negativos.

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Prepubertal testicular tumors in China: a 10-year experience with 67 cases

Cited by 21 publications

References 24 publications

Testis Sparing Surgery in Pediatric Testicular Tumors

Testis Sparing Surgery in Pediatric Testicular Tumors

Epidermoid Cyst of the Testis 5-Year Follow-Up Results in Adults

Lesión quística testicular en un lactante: consideraciones diagnósticas y terapéuticas

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