Prepulse inhibition in the rat is regulated by ventral and caudodorsal striato-pallidal circuitry.

Abstract

It has been shown that the acoustic startle reflex is inhibited by weak auditory prepulses presented 30-500 ms prior to the startling stimulus and that this prepulse inhibition (PPI) is modulated by ventral striato-pallidal circuitry. However, dorsal striatal modulation of PPI has not been examined. Cell-specific lesions and intracerebral drug infusions were used to elucidate striatal modulation of PPI. Quinolinic acid lesions of the ventral and caudodorsal striatum significantly decreased PPI, whereas lesions of the rostrodorsal and middorsal striatum did not significantly alter PPI. Infusion of the GABA-A antagonist picrotoxin into the ventral and caudal dorsal pallidum also significantly reduced PPI, whereas rostral pallidal picrotoxin infusion had no significant effect. Thus, PPI in the rat seems to be modulated by both ventral and caudodorsal striato-pallidal circuitry, but not by rostrodorsal or middorsal striato-pallidal projections.

Neurotensin-Deficient Mice Have Deficits in Prepulse Inhibition: Restoration by Clozapine but Not Haloperidol, Olanzapine, or Quetiapine

“…However, the opposite result was obtained for haloperidol-induced hypolocomotion, indicating that NT may differentially influence diverse EPS (Casti et al, 2004). Although the rodent dorsolateral striatum is typically considered to be a motor area, lesions in the caudodorsal striatum have been demonstrated to decrease basal PPI (Kodsi and Swerdlow, 1995), suggesting that haloperidol-mediated increases in neuronal activity in this region could influence PPI. In fact, although the majority of evidence has implicated NT in the nucleus accumbens as mediating the antipsychotic-like effects of NT, NT seems to play a more important role in haloperidol-evoked Fos expression in the striatal patch compartment , which has been implicated in affective and cognitive functions (Moratalla et al, 1992;White and Hiroi, 1998;Canales and Graybiel, 2000).…”

A Cyclooxygenase-2 Inhibitor Ameliorates Behavioral Impairments Induced by Striatal Administration of Epidermal Growth Factor

“…Enhanced dopamine signaling in both ventral and dorsal striatum is implicated in PPI deficits (Kodsi and Swerdlow, 1995;Swerdlow et al, 2001). Among the striatal regions, the nucleus accumbens is suggested to play an important role in regulating PPI (Swerdlow et al, 1990).…”

Environmental stimulation increases survival in mice transgenic for exon 1 of the Huntington's disease gene

“…The most important of these have been the excitotoxic and 3-nitropropionic acid (3-NP) models in which HD-like neuropathologic, motor, and cognitive changes have been reported. [3][4][5][6][7][8][9][10][11][12] However, one of the major disadvantages of such models is that because they are neurochemically induced, they lack the truly progressive changes that are a hallmark feature of HD.…”