Prepulse inhibition modulation by contextual conditioning of dopaminergic activity

Mena, Auxiliadora; Casa, L.G. De la

doi:10.1016/j.bbr.2013.06.005

Cited by 11 publications

(8 citation statements)

References 44 publications

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“…Amphetamine (3 mg/kg) was dissolved in saline solution. The dose was selected because it was effective in previous experiments (Mena & De la Casa, 2013). The control group received injections of saline (0.9%).…”

Section: Methodsmentioning

confidence: 99%

Sensitivity to amphetamine in prepulse inhibition response requires a mature medial prefrontal cortex.

Mena¹,

López²,

Ruiz-Salas³

et al. 2021

Behavioral Neuroscience

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Prepulse inhibition (PPI) refers to the modulation of the startle response by the presentation of a weaker stimulus prior to the onset of the startle stimulus. This response is consolidated along the maturation process of the mesocortical system, where the dopamine neurotransmitter plays an important role. In fact, it has been reported that agonist and antagonist dopaminergic drugs are able to change PPI expression. This study was aimed to analyze the relationship between the adult medial prefrontal cortex (mPfc) and dopaminergic involvement in PPI throughout the life span. Specifically, the present experiment analyzed the effect of the administration of dopaminergic agonist amphetamine on PPI in two different age periods in Wistar rats: postnatal day (PND) 28 and PND 70. In this last period, we also explored the relationship between PPI response and amphetamine effects after mPfc lesion. The results showed that PPI was expressed in all groups and periods; however, amphetamine only modulated this effect during adulthood. We also found that the mPfc is essential to modulate PPI after amphetamine consumption. Besides, our results suggest a role for dopamine and mPfc as important modulators of PPI in adulthood. Nevertheless, this neurotransmitter could not be involved in the expression of PPI because the administration of a dopaminergic agonist was ineffective in PND-28 period.

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Section: Methodsmentioning

confidence: 99%

Sensitivity to amphetamine in prepulse inhibition response requires a mature medial prefrontal cortex.

Mena¹,

López²,

Ruiz-Salas³

et al. 2021

Behavioral Neuroscience

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“…Pavlov [1] described some experiments to show that repeated morphine administration in the presence of an experimental context resulted in a conditioned response to that context that mimicked some of the unconditional properties of morphine, such as nausea, vomiting, excessive salivation, or sleeping. Subsequently, ample experimental evidence has demonstrated conditioning using the effects of many different drugs as the Unconditioned Stimulus (US) [2,3,4,5]. These studies have focused not only on analyzing the learned associations that emerge after pairing the Conditioned Stimulus (CS) and the US [6,7,8], while also identifying the structures and neural circuits that constitute the neurobiological bases of learning [9,10,11,12], and the causes of drug addictions since conditioning has been proposed as a potential trigger of relapse and tolerance [13,14,15].…”

Section: Introductionmentioning

confidence: 99%

Unconditioned and Conditioned Anxiolytic Effects of Sodium Valproate on Flavor Neophobia and Fear Conditioning

Cintado

González-Tirado

Cárcel

et al. 2022

Preprint

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In three experiments with rats, we analyzed the potential anxiolytic effects of sodium valproate, an anticonvulsant drug that has shown additional pharmacodynamic effects in animal models, including anxiolytic action. Since previous results have revealed that injecting valproate before allowing animals to consume a novel flavor solution resulted in an attenuation of neophobia, we predicted a similar effect when the novel flavor is presented on a drug-free trial in the presence of a context previously associated with the drug. In line with this hypothesis, in our first experiment we observed a reduction in neophobia to a novel flavor for those animals tested in the presence of the context associated with Sodium Valproate. However, a control group that received the drug before being allowed access to the novel flavor showed a significant reduction in consumption. Experiment 2 revealed that the unconditioned effects of the drug include a deleterious effect on the animals' locomotor activity that probably interferes with drinking behavior. Finally, in a third experiment, we directly tested the potential anxiolytic properties of sodium valproate by injecting the drug before implementing a fear conditioning procedure. These findings are explained in terms of the unconditioned anxiolytic action of the drug and the formation of an association between the context and the effects of the drug that evokes a conditioned response reminiscent of such anxiolytic effect.

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“…Pavlov (1849Pavlov ( -1936, who reported that repeated administration of morphine in the presence of the same context resulted in Conditioned Responses (CR) similar to those produced by the drug itself (Pavlov, 1927). Based on these pioneering studies, numerous investigations have been conducted demonstrating the conditioning of various responses produced by a wide range of drugs, and revealing that sometimes the CR was similar to that induced by the drug (e.g., Battisti et al, 2000;Mena and De la Casa, 2013), while in other cases the CR was opposite to the unconditioned effect of the drug (e.g., Siegel, 1975;Solomon, 1980). To explain these differences, Eikelboom and Stewart (1982) proposed that on some occasions the Conditioned Stimulus (CS) would be associated with a response that depends on the central nervous system, while others times it would be associated with a peripheral response which appears to compensate the effect of the drug.…”

Section: Introductionmentioning

confidence: 99%

Temporal Factors Modulate Haloperidol-Induced Conditioned Catalepsy

Cárcel

Casa

2021

Front. Behav. Neurosci.

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Repeated pairings of a neutral context and the effects of haloperidol give rise to conditioned catalepsy when the context is subsequently presented in a drug-free test. In order to confirm whether this response is based on Pavlovian processes, we conducted two experiments involving two manipulations that affect conditioning intensity in classical conditioning procedures: time of joint exposure to the conditioned and the unconditioned stimulus, and the length of the inter-stimulus interval (ISI). The results revealed that both an increase in the length of context-drug pairings during conditioning and a reduced ISI between drug administration and context exposure increased conditioned catalepsy. These results are discussed in terms of the temporal peculiarities of those procedures that involve drugs as the unconditioned stimulus along with the role of Pavlovian conditioning in context-dependent catalepsy.

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Prepulse inhibition modulation by contextual conditioning of dopaminergic activity

Cited by 11 publications

References 44 publications

Sensitivity to amphetamine in prepulse inhibition response requires a mature medial prefrontal cortex.

Sensitivity to amphetamine in prepulse inhibition response requires a mature medial prefrontal cortex.

Unconditioned and Conditioned Anxiolytic Effects of Sodium Valproate on Flavor Neophobia and Fear Conditioning

Temporal Factors Modulate Haloperidol-Induced Conditioned Catalepsy

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