Background:Phimosis is non-retractile foreskin or prepuce over the glans. This is due flimsy adhesions between glans and prepuce. The two types of phimosis, physiological and pathological must be differentiated. The phimosis can be treated by conservative methods by application of topical steroid cream. The objective of this study was to evaluate the efficacy of nonsurgical separation and topical clobetasol propionate 0.05% cream therapy in treatment of phimosis.Methods: This study was done on 62 patients presenting with symptoms of phimosis were included in the study. The clinical examination prepuce and penis was done. The patients were classified according to Kirkiros classification. In this classification of phimosis, 5 grades have been ascribed according to the retractibility of prepuce.Results:Out of total 62 patients, the complete response was obtained in 55 (80.71%), partial response in 5 (8.06%) and no response in 2 (3.23%) patients. In patients with partial response the topical clobetasol therapy, the treatment was repeated for another 4 weeks. The phimotic ring disappeared in all the patients after 4 or 8 weeks of topical clobetasol propionate 0.05% cream application. The surgical therapy either circumcision or preputioplasty should be done only in selected cases.Conclusions:This study concludes that nonsurgical separation and topical clobetasol cream therapy is quite effective for treatment of phimosis.