Preretinal and Optic Nerve Head Neovascularization Induced by Photodynamic Venous Thrombosis in Domestic Pigs

Development of a New Mouse Model of Branch Retinal Vein Occlusion and Retinal Neovascularization

“…Models of retinal NV secondary to photodynamic venous thrombosis have been established in domestic pigs and rats, [6][7][8][9] and have provided useful information about approaches to antiangiogenic therapy. 15,16 In this study, we developed and characterized a mouse model of branch retinal vein occlusion and retinal NV.…”

Experimental preretinal neovascularization by laser-induced venous thrombosis in rats

“…Danis et al (10) increased the rate of successful production of NV with the use of rose bengal dye and repeating laser treatment. In our model using rats, the NV developed 70% without repeating the laser treatment.…”

“…These studies have used non human primates (4)(5)(6), rabbits (7), cats (8,9) and pigs (10,11). The most popular methods used recently are an argon laser or a dye yellow laser photocoagulation on the primates' retinal veins, which can make NV of the iris caused by total retinal ischemia (4,6).…”

Intravitreous anti-raf-1 kinase antisense oligonucleotide as an angioinhibitory agent in porcine preretinal neovascularization

“…BVOs were created in both eyes of 7 weanling male farm pigs in a manner described previously. 12 After intravenous injection of Rose Bengal dye 10 mg/kg (Sigma, St. Louis), selected branch retinal veins were treated with an argon green laser using a slit lamp delivery system and a corneal contact lens. At least 50% of the total venous territory of the retina was occluded.…”