PReS-FINAL-2149: Interaction of PTPN2 and vitamin D GC sequence variants and risk of juvenile idiopathic arthritis

The impact of genetic variants related to vitamin D and autoimmunity: A systematic review

“…Ramagopalan et al using a ChIP-seq approach demonstrated that VDR has an intronic binding site in the PTPN2 gene. These findings, together with some genetic association studies, may support the role of PTPN2 on autoimmune diseases [ [128] , [129] , [130] ]. PTPN2 exhibits ubiquitous expression and serves as a signaling molecule that regulates various cellular processes, encompassing cell growth, differentiation, mitotic cycle, oncogenic transformation and regulating inflammatory signaling [ [131] , [132] , [133] , [134] ].…”