Presacral ganglioneuroma arising in an elderly man with persistent constipation

Okai, Takashi; Minamoto, Toshinari; Ohtsubo, Koushiro; Kitagata, H.; Kadoya, Masumi; Oda, Yoshio; Sawabu, Norio

doi:10.1007/s002610000133

Cited by 10 publications

(4 citation statements)

References 9 publications

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“…The prognosis after surgical resection of GN, even if it is subtotal seems to be excellent. Nor neoadjuvant nor adjuvant chemotherapy or radiotherapy are indicated due to the benign nature of the disease [3,5,22,23]. Long-term clinical and radiological follow-up after incomplete resection is necessary, because the local progression of the residual tumor, recurrence of symptoms, and malignant transformation may occur [5,7,23,24].…”

Section: Discussionmentioning

confidence: 99%

“…Nor neoadjuvant nor adjuvant chemotherapy or radiotherapy are indicated due to the benign nature of the disease [3,5,22,23]. Long-term clinical and radiological follow-up after incomplete resection is necessary, because the local progression of the residual tumor, recurrence of symptoms, and malignant transformation may occur [5,7,23,24]. Redo surgery would be discussed only in the case of progression of the residual tumor more than 25% of the initial size [8] or malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

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Pediatric case of presacral ganglioneuroma: diagnostic considerations and therapeutic strategy

et al. 2021

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Background Ganglioneuroma (GN) is an uncommon tumor belonging to the neuroblastic tumors group and is often localized in the posterior mediastinum, retroperitoneum, and adrenal gland. Presacral (PS) location is extremely rare. Its management remains a challenge. Case presentation A 4-year-old child presented to our department for an isolated abdominal mass. Para-clinical exams concluded to PSGN. Subtotal surgical excision was performed through an anterior transperitoneal approach. The size of the residual tumor did not progress after the 6-year follow-up period and the patients were asymptomatic. Conclusions GN should be considered in the case of soft tissue presacral masses in pediatrics. Subtotal resection seems sufficient in case of an extension to the sacrum with low morbidity. The residual tumors are still stable and the prognosis seems conserved. Further, long-term follow-up in large studies is needed to confirm these findings.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pediatric case of presacral ganglioneuroma: diagnostic considerations and therapeutic strategy

et al. 2021

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“…They are often asymptomatic, but a variety of nonspecific symptoms have been attributed to local mass effects on adjacent structures. Especially, for presacral GNs, low back and leg pain, bilateral hip pain, constipation, amenorrhea and neurogenic bladder have been reported in various studies as main symptoms [6, 11, 12, 13, 14]. Moreover, patients with GN (approx.…”

Section: Discussionmentioning

confidence: 99%

Presacral Ganglioneuroma: Diagnostic Considerations and Therapeutic Strategy

et al. 2013

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Presacral ganglioneuroma is an extremely rare tumor of neural crest origin. To the best of our knowledge, less than 20 cases have been reported previously. The present study reports on a presacral ganglioneuroma, 10.5 × 8 × 4 cm in size, that was found incidentally in a 35-year-old man with prior history of diverticulitis. He was admitted to our hospital due to lower left abdominal pain. Abdominal computed tomography and magnetic resonance imaging confirmed the extension of the lesion from the S2 level to the coccyx. The mass had low signal intensity on T1-weighted images and heterogeneous high signal intensity on T2-weighted images with no intraspinal or rectal extension. T2-weighted images demonstrated a compartmentalized solid tumor with cystic components. Complete tumor resection with free surgical margins was achieved using an abdominal approach. The patient remains asymptomatic 2 years after surgery. We emphasize on clinical features, radiologic appearance and surgical treatment of this rare entity. The clinical and pathologic features of previously reported studies are also briefly reviewed.

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“…2). 3,15 There are also several reports in the literature in which authors have described malignant transformation of ganglioneuromas either spontaneously or after radiation therapy. 3,5,10,12 In patients with neuroblastomas that have matured into ganglioneuromas the prognosis is excellent.…”

Section: Discussionmentioning

confidence: 99%